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Macrophages as a Potential Immunotherapeutic Target in Solid Cancers

The revolution in cancer immunotherapy over the last few decades has resulted in a paradigm shift in the clinical care of cancer. Most of the cancer immunotherapeutic regimens approved so far have relied on modulating the adaptive immune system. In recent years, strategies and approaches targeting t...

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Autores principales: Mishra, Alok K., Banday, Shahid, Bharadwaj, Ravi, Ali, Amjad, Rashid, Romana, Kulshreshtha, Ankur, Malonia, Sunil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863216/
https://www.ncbi.nlm.nih.gov/pubmed/36679900
http://dx.doi.org/10.3390/vaccines11010055
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author Mishra, Alok K.
Banday, Shahid
Bharadwaj, Ravi
Ali, Amjad
Rashid, Romana
Kulshreshtha, Ankur
Malonia, Sunil K.
author_facet Mishra, Alok K.
Banday, Shahid
Bharadwaj, Ravi
Ali, Amjad
Rashid, Romana
Kulshreshtha, Ankur
Malonia, Sunil K.
author_sort Mishra, Alok K.
collection PubMed
description The revolution in cancer immunotherapy over the last few decades has resulted in a paradigm shift in the clinical care of cancer. Most of the cancer immunotherapeutic regimens approved so far have relied on modulating the adaptive immune system. In recent years, strategies and approaches targeting the components of innate immunity have become widely recognized for their efficacy in targeting solid cancers. Macrophages are effector cells of the innate immune system, which can play a crucial role in the generation of anti-tumor immunity through their ability to phagocytose cancer cells and present tumor antigens to the cells of adaptive immunity. However, the macrophages that are recruited to the tumor microenvironment predominantly play pro-tumorigenic roles. Several strategies targeting pro-tumorigenic functions and harnessing the anti-tumorigenic properties of macrophages have shown promising results in preclinical studies, and a few of them have also advanced to clinical trials. In this review, we present a comprehensive overview of the pathobiology of TAMs and their role in the progression of solid malignancies. We discuss various mechanisms through which TAMs promote tumor progression, such as inflammation, genomic instability, tumor growth, cancer stem cell formation, angiogenesis, EMT and metastasis, tissue remodeling, and immunosuppression, etc. In addition, we also discuss potential therapeutic strategies for targeting TAMs and explore how macrophages can be used as a tool for next-generation immunotherapy for the treatment of solid malignancies.
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spelling pubmed-98632162023-01-22 Macrophages as a Potential Immunotherapeutic Target in Solid Cancers Mishra, Alok K. Banday, Shahid Bharadwaj, Ravi Ali, Amjad Rashid, Romana Kulshreshtha, Ankur Malonia, Sunil K. Vaccines (Basel) Review The revolution in cancer immunotherapy over the last few decades has resulted in a paradigm shift in the clinical care of cancer. Most of the cancer immunotherapeutic regimens approved so far have relied on modulating the adaptive immune system. In recent years, strategies and approaches targeting the components of innate immunity have become widely recognized for their efficacy in targeting solid cancers. Macrophages are effector cells of the innate immune system, which can play a crucial role in the generation of anti-tumor immunity through their ability to phagocytose cancer cells and present tumor antigens to the cells of adaptive immunity. However, the macrophages that are recruited to the tumor microenvironment predominantly play pro-tumorigenic roles. Several strategies targeting pro-tumorigenic functions and harnessing the anti-tumorigenic properties of macrophages have shown promising results in preclinical studies, and a few of them have also advanced to clinical trials. In this review, we present a comprehensive overview of the pathobiology of TAMs and their role in the progression of solid malignancies. We discuss various mechanisms through which TAMs promote tumor progression, such as inflammation, genomic instability, tumor growth, cancer stem cell formation, angiogenesis, EMT and metastasis, tissue remodeling, and immunosuppression, etc. In addition, we also discuss potential therapeutic strategies for targeting TAMs and explore how macrophages can be used as a tool for next-generation immunotherapy for the treatment of solid malignancies. MDPI 2022-12-26 /pmc/articles/PMC9863216/ /pubmed/36679900 http://dx.doi.org/10.3390/vaccines11010055 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mishra, Alok K.
Banday, Shahid
Bharadwaj, Ravi
Ali, Amjad
Rashid, Romana
Kulshreshtha, Ankur
Malonia, Sunil K.
Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title_full Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title_fullStr Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title_full_unstemmed Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title_short Macrophages as a Potential Immunotherapeutic Target in Solid Cancers
title_sort macrophages as a potential immunotherapeutic target in solid cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863216/
https://www.ncbi.nlm.nih.gov/pubmed/36679900
http://dx.doi.org/10.3390/vaccines11010055
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