Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen express...

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Detalles Bibliográficos
Autores principales: Schmidt, Christin, Schnierle, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863218/
https://www.ncbi.nlm.nih.gov/pubmed/36678486
http://dx.doi.org/10.3390/pathogens12010138
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author Schmidt, Christin
Schnierle, Barbara S.
author_facet Schmidt, Christin
Schnierle, Barbara S.
author_sort Schmidt, Christin
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description The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.
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spelling pubmed-98632182023-01-22 Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development Schmidt, Christin Schnierle, Barbara S. Pathogens Review The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed. MDPI 2023-01-13 /pmc/articles/PMC9863218/ /pubmed/36678486 http://dx.doi.org/10.3390/pathogens12010138 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schmidt, Christin
Schnierle, Barbara S.
Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title_full Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title_fullStr Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title_full_unstemmed Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title_short Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development
title_sort self-amplifying rna vaccine candidates: alternative platforms for mrna vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863218/
https://www.ncbi.nlm.nih.gov/pubmed/36678486
http://dx.doi.org/10.3390/pathogens12010138
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