A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies

As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active pos...

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Autores principales: Ming, Hui, Zhang, Kunpeng, Ge, Shengbo, Shi, Yang, Du, Chunan, Guo, Xuqiang, Zhang, Libo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863240/
https://www.ncbi.nlm.nih.gov/pubmed/36677977
http://dx.doi.org/10.3390/nano13020224
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author Ming, Hui
Zhang, Kunpeng
Ge, Shengbo
Shi, Yang
Du, Chunan
Guo, Xuqiang
Zhang, Libo
author_facet Ming, Hui
Zhang, Kunpeng
Ge, Shengbo
Shi, Yang
Du, Chunan
Guo, Xuqiang
Zhang, Libo
author_sort Ming, Hui
collection PubMed
description As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
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spelling pubmed-98632402023-01-22 A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies Ming, Hui Zhang, Kunpeng Ge, Shengbo Shi, Yang Du, Chunan Guo, Xuqiang Zhang, Libo Nanomaterials (Basel) Review As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation. MDPI 2023-01-04 /pmc/articles/PMC9863240/ /pubmed/36677977 http://dx.doi.org/10.3390/nano13020224 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ming, Hui
Zhang, Kunpeng
Ge, Shengbo
Shi, Yang
Du, Chunan
Guo, Xuqiang
Zhang, Libo
A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title_full A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title_fullStr A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title_full_unstemmed A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title_short A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
title_sort mini review of s-nitrosoglutathione loaded nano/micro-formulation strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863240/
https://www.ncbi.nlm.nih.gov/pubmed/36677977
http://dx.doi.org/10.3390/nano13020224
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