Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition

Colorectal cancer (CRC) is the second deadliest cancer in the world. Besides APC and p53 alterations, the PI3K/AKT/MTOR and MAPK pathway are most commonly mutated in CRC. So far, no treatment options targeting these pathways are available in routine clinics for CRC patients. We systematically analyz...

Descripción completa

Detalles Bibliográficos
Autores principales: Atanasova, Velina S., Riedl, Angelika, Strobl, Marcus, Flandorfer, Julia, Unterleuthner, Daniela, Weindorfer, Claudia, Neuhold, Patrick, Stang, Simone, Hengstschläger, Markus, Bergmann, Michael, Dolznig, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863259/
https://www.ncbi.nlm.nih.gov/pubmed/36675180
http://dx.doi.org/10.3390/ijms24021668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863259/
https://www.ncbi.nlm.nih.gov/pubmed/36675180
http://dx.doi.org/10.3390/ijms24021668

Ejemplares similares