Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition

Colorectal cancer (CRC) is the second deadliest cancer in the world. Besides APC and p53 alterations, the PI3K/AKT/MTOR and MAPK pathway are most commonly mutated in CRC. So far, no treatment options targeting these pathways are available in routine clinics for CRC patients. We systematically analyz...

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Detalles Bibliográficos
Autores principales: Atanasova, Velina S., Riedl, Angelika, Strobl, Marcus, Flandorfer, Julia, Unterleuthner, Daniela, Weindorfer, Claudia, Neuhold, Patrick, Stang, Simone, Hengstschläger, Markus, Bergmann, Michael, Dolznig, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863259/
https://www.ncbi.nlm.nih.gov/pubmed/36675180
http://dx.doi.org/10.3390/ijms24021668

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