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Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids

Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic l...

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Autores principales: Michalski, Jakub, Sommer, Julia, Rossmanith, Peter, Syguda, Anna, Clapa, Tomasz, Mester, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863300/
https://www.ncbi.nlm.nih.gov/pubmed/36675201
http://dx.doi.org/10.3390/ijms24021686
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author Michalski, Jakub
Sommer, Julia
Rossmanith, Peter
Syguda, Anna
Clapa, Tomasz
Mester, Patrick
author_facet Michalski, Jakub
Sommer, Julia
Rossmanith, Peter
Syguda, Anna
Clapa, Tomasz
Mester, Patrick
author_sort Michalski, Jakub
collection PubMed
description Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec(2)Mor](+) based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure.
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spelling pubmed-98633002023-01-22 Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids Michalski, Jakub Sommer, Julia Rossmanith, Peter Syguda, Anna Clapa, Tomasz Mester, Patrick Int J Mol Sci Article Witnessed by the ongoing spread of antimicrobial resistant bacteria as well as the recent global pandemic of the SARS-CoV-2 virus, the development of new disinfection strategies is of great importance, and novel substance classes as effective antimicrobials and virucides are urgently needed. Ionic liquids (ILs), low-melting salts, have been already recognized as efficient antimicrobial agents with prospects for antiviral potential. In this study, we examined the antiviral activity of 12 morpholinium based herbicidal ionic liquids with a tripartite test system, including enzyme inhibition tests, virucidal activity determination against five model viruses and activity against five bacterial species. The antimicrobial and enzymatic tests confirmed that the inhibiting activity of ILs corresponds with the number of long alkyl side chains and that [Dec(2)Mor](+) based ILs are promising candidates as novel antimicrobials. The virucidal tests showed that ILs antiviral activity depends on the type and structure of the virus, revealing enveloped Phi6 phage as highly susceptible to the ILs action, while the non-enveloped phages PRD1 and MS2 proved completely resistant to ionic liquids. Furthermore, a comparison of results obtained for P100 and P001 phages demonstrated for the first time that the susceptibility of viruses to ionic liquids can be dependent on differences in the phage tail structure. MDPI 2023-01-14 /pmc/articles/PMC9863300/ /pubmed/36675201 http://dx.doi.org/10.3390/ijms24021686 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Michalski, Jakub
Sommer, Julia
Rossmanith, Peter
Syguda, Anna
Clapa, Tomasz
Mester, Patrick
Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title_full Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title_fullStr Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title_full_unstemmed Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title_short Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
title_sort antimicrobial and virucidal potential of morpholinium-based ionic liquids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863300/
https://www.ncbi.nlm.nih.gov/pubmed/36675201
http://dx.doi.org/10.3390/ijms24021686
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