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Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863311/ https://www.ncbi.nlm.nih.gov/pubmed/36679881 http://dx.doi.org/10.3390/vaccines11010036 |
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author | Ambrogio, Francesca Laface, Carmelo De Caro, Anna Paola Loconsole, Daniela Centrone, Francesca Lettini, Teresa Cazzato, Gerardo Bonamonte, Domenico Foti, Caterina Chironna, Maria Romita, Paolo |
author_facet | Ambrogio, Francesca Laface, Carmelo De Caro, Anna Paola Loconsole, Daniela Centrone, Francesca Lettini, Teresa Cazzato, Gerardo Bonamonte, Domenico Foti, Caterina Chironna, Maria Romita, Paolo |
author_sort | Ambrogio, Francesca |
collection | PubMed |
description | Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first time in countries where the disease is not endemic and without cases having direct or immediate epidemiological links to areas of West or Central Africa (travel, importation of mammals). On 23 July 2022, WHO declared monkeypox a “Public Emergency of International Concern” (PHEIC). In this paper, we report two cases of a Polymerase Chain Reaction (PCR)-confirmed MPXV infection. A 39-year-old Italian male came to our attention for a suspected herpetic infection, fever, headache, and malaise, which were followed by the development of an erythematous plaque covered by vesicles on the chin, an oval ulcer with a white peripheral border on the lower lip, and a central erosive area and three pustules on the arms and trunk. During the physical examination, cervical lymphadenopathy was also detected. PCR investigation of the patient and his partner confirmed the presence of MPXV infection. Our report describes a possible clinical feature of Mpox disease and illustrates the challenge of a disease that seems to present itself in different ways. |
format | Online Article Text |
id | pubmed-9863311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98633112023-01-22 Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings Ambrogio, Francesca Laface, Carmelo De Caro, Anna Paola Loconsole, Daniela Centrone, Francesca Lettini, Teresa Cazzato, Gerardo Bonamonte, Domenico Foti, Caterina Chironna, Maria Romita, Paolo Vaccines (Basel) Case Report Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first time in countries where the disease is not endemic and without cases having direct or immediate epidemiological links to areas of West or Central Africa (travel, importation of mammals). On 23 July 2022, WHO declared monkeypox a “Public Emergency of International Concern” (PHEIC). In this paper, we report two cases of a Polymerase Chain Reaction (PCR)-confirmed MPXV infection. A 39-year-old Italian male came to our attention for a suspected herpetic infection, fever, headache, and malaise, which were followed by the development of an erythematous plaque covered by vesicles on the chin, an oval ulcer with a white peripheral border on the lower lip, and a central erosive area and three pustules on the arms and trunk. During the physical examination, cervical lymphadenopathy was also detected. PCR investigation of the patient and his partner confirmed the presence of MPXV infection. Our report describes a possible clinical feature of Mpox disease and illustrates the challenge of a disease that seems to present itself in different ways. MDPI 2022-12-23 /pmc/articles/PMC9863311/ /pubmed/36679881 http://dx.doi.org/10.3390/vaccines11010036 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Ambrogio, Francesca Laface, Carmelo De Caro, Anna Paola Loconsole, Daniela Centrone, Francesca Lettini, Teresa Cazzato, Gerardo Bonamonte, Domenico Foti, Caterina Chironna, Maria Romita, Paolo Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title | Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title_full | Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title_fullStr | Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title_full_unstemmed | Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title_short | Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings |
title_sort | peri-oral monkeypox virus infection: a clinical report with confirmatory polymerase chain reaction findings |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863311/ https://www.ncbi.nlm.nih.gov/pubmed/36679881 http://dx.doi.org/10.3390/vaccines11010036 |
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