Cargando…

Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings

Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambrogio, Francesca, Laface, Carmelo, De Caro, Anna Paola, Loconsole, Daniela, Centrone, Francesca, Lettini, Teresa, Cazzato, Gerardo, Bonamonte, Domenico, Foti, Caterina, Chironna, Maria, Romita, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863311/
https://www.ncbi.nlm.nih.gov/pubmed/36679881
http://dx.doi.org/10.3390/vaccines11010036
_version_ 1784875302457966592
author Ambrogio, Francesca
Laface, Carmelo
De Caro, Anna Paola
Loconsole, Daniela
Centrone, Francesca
Lettini, Teresa
Cazzato, Gerardo
Bonamonte, Domenico
Foti, Caterina
Chironna, Maria
Romita, Paolo
author_facet Ambrogio, Francesca
Laface, Carmelo
De Caro, Anna Paola
Loconsole, Daniela
Centrone, Francesca
Lettini, Teresa
Cazzato, Gerardo
Bonamonte, Domenico
Foti, Caterina
Chironna, Maria
Romita, Paolo
author_sort Ambrogio, Francesca
collection PubMed
description Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first time in countries where the disease is not endemic and without cases having direct or immediate epidemiological links to areas of West or Central Africa (travel, importation of mammals). On 23 July 2022, WHO declared monkeypox a “Public Emergency of International Concern” (PHEIC). In this paper, we report two cases of a Polymerase Chain Reaction (PCR)-confirmed MPXV infection. A 39-year-old Italian male came to our attention for a suspected herpetic infection, fever, headache, and malaise, which were followed by the development of an erythematous plaque covered by vesicles on the chin, an oval ulcer with a white peripheral border on the lower lip, and a central erosive area and three pustules on the arms and trunk. During the physical examination, cervical lymphadenopathy was also detected. PCR investigation of the patient and his partner confirmed the presence of MPXV infection. Our report describes a possible clinical feature of Mpox disease and illustrates the challenge of a disease that seems to present itself in different ways.
format Online
Article
Text
id pubmed-9863311
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98633112023-01-22 Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings Ambrogio, Francesca Laface, Carmelo De Caro, Anna Paola Loconsole, Daniela Centrone, Francesca Lettini, Teresa Cazzato, Gerardo Bonamonte, Domenico Foti, Caterina Chironna, Maria Romita, Paolo Vaccines (Basel) Case Report Mpox Virus (MPXV) is a zoonotic infectious disease first identified in 1970 in rural villages in rainforest areas of central and western Africa when smallpox was in the final stages of eradication. Since May 2022, cases and sustained transmission chains of monkeypox have been reported for the first time in countries where the disease is not endemic and without cases having direct or immediate epidemiological links to areas of West or Central Africa (travel, importation of mammals). On 23 July 2022, WHO declared monkeypox a “Public Emergency of International Concern” (PHEIC). In this paper, we report two cases of a Polymerase Chain Reaction (PCR)-confirmed MPXV infection. A 39-year-old Italian male came to our attention for a suspected herpetic infection, fever, headache, and malaise, which were followed by the development of an erythematous plaque covered by vesicles on the chin, an oval ulcer with a white peripheral border on the lower lip, and a central erosive area and three pustules on the arms and trunk. During the physical examination, cervical lymphadenopathy was also detected. PCR investigation of the patient and his partner confirmed the presence of MPXV infection. Our report describes a possible clinical feature of Mpox disease and illustrates the challenge of a disease that seems to present itself in different ways. MDPI 2022-12-23 /pmc/articles/PMC9863311/ /pubmed/36679881 http://dx.doi.org/10.3390/vaccines11010036 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ambrogio, Francesca
Laface, Carmelo
De Caro, Anna Paola
Loconsole, Daniela
Centrone, Francesca
Lettini, Teresa
Cazzato, Gerardo
Bonamonte, Domenico
Foti, Caterina
Chironna, Maria
Romita, Paolo
Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title_full Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title_fullStr Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title_full_unstemmed Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title_short Peri-oral Monkeypox Virus Infection: A Clinical Report with Confirmatory Polymerase Chain Reaction Findings
title_sort peri-oral monkeypox virus infection: a clinical report with confirmatory polymerase chain reaction findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863311/
https://www.ncbi.nlm.nih.gov/pubmed/36679881
http://dx.doi.org/10.3390/vaccines11010036
work_keys_str_mv AT ambrogiofrancesca perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT lafacecarmelo perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT decaroannapaola perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT loconsoledaniela perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT centronefrancesca perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT lettiniteresa perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT cazzatogerardo perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT bonamontedomenico perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT foticaterina perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT chironnamaria perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings
AT romitapaolo perioralmonkeypoxvirusinfectionaclinicalreportwithconfirmatorypolymerasechainreactionfindings