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Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series

We describe the clinical presentation, radiological findings, treatment and outcomes of three patients with delayed leukoencephalopathy occurring after endovascular treatment (EVT) for cerebral aneurysms—a rare, albeit recurring, complication. The symptoms occurred 6 to 12 months following the EVT o...

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Autores principales: Bakola, Eleni, Papagiannopoulou, Georgia, Palaiodimou, Lina, Lagios, Konstantinos, Archontakis, Eftychios, Theodorou, Aikaterini, Katsanos, Aristeidis H., Triantafyllou, Sokratis, Zouvelou, Vasiliki, Lachanis, Stefanos, Tzanetakos, Dimitrios, Tzartos, John S., Giannopoulos, Sotirios, Tsivgoulis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863316/
https://www.ncbi.nlm.nih.gov/pubmed/36675425
http://dx.doi.org/10.3390/jcm12020496
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author Bakola, Eleni
Papagiannopoulou, Georgia
Palaiodimou, Lina
Lagios, Konstantinos
Archontakis, Eftychios
Theodorou, Aikaterini
Katsanos, Aristeidis H.
Triantafyllou, Sokratis
Zouvelou, Vasiliki
Lachanis, Stefanos
Tzanetakos, Dimitrios
Tzartos, John S.
Giannopoulos, Sotirios
Tsivgoulis, Georgios
author_facet Bakola, Eleni
Papagiannopoulou, Georgia
Palaiodimou, Lina
Lagios, Konstantinos
Archontakis, Eftychios
Theodorou, Aikaterini
Katsanos, Aristeidis H.
Triantafyllou, Sokratis
Zouvelou, Vasiliki
Lachanis, Stefanos
Tzanetakos, Dimitrios
Tzartos, John S.
Giannopoulos, Sotirios
Tsivgoulis, Georgios
author_sort Bakola, Eleni
collection PubMed
description We describe the clinical presentation, radiological findings, treatment and outcomes of three patients with delayed leukoencephalopathy occurring after endovascular treatment (EVT) for cerebral aneurysms—a rare, albeit recurring, complication. The symptoms occurred 6 to 12 months following the EVT of the cerebral aneurysm. Characteristic imaging findings included high-signal changes on T2 images in the white matter without diffusion restriction predominantly at the distribution of the vascular territory of the catheterized arteries, coupled with patchy gadolinium enhancement or low susceptibility weighted imaging (SWI) signals within the white-matter lesions. Steroid pulse therapy is the treatment of choice and promptly improves clinical and imaging findings. Tapering or cessation of steroids may result in clinical and imaging relapses; close- and long-term follow-up for patients presenting this complication is warranted.
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spelling pubmed-98633162023-01-22 Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series Bakola, Eleni Papagiannopoulou, Georgia Palaiodimou, Lina Lagios, Konstantinos Archontakis, Eftychios Theodorou, Aikaterini Katsanos, Aristeidis H. Triantafyllou, Sokratis Zouvelou, Vasiliki Lachanis, Stefanos Tzanetakos, Dimitrios Tzartos, John S. Giannopoulos, Sotirios Tsivgoulis, Georgios J Clin Med Case Report We describe the clinical presentation, radiological findings, treatment and outcomes of three patients with delayed leukoencephalopathy occurring after endovascular treatment (EVT) for cerebral aneurysms—a rare, albeit recurring, complication. The symptoms occurred 6 to 12 months following the EVT of the cerebral aneurysm. Characteristic imaging findings included high-signal changes on T2 images in the white matter without diffusion restriction predominantly at the distribution of the vascular territory of the catheterized arteries, coupled with patchy gadolinium enhancement or low susceptibility weighted imaging (SWI) signals within the white-matter lesions. Steroid pulse therapy is the treatment of choice and promptly improves clinical and imaging findings. Tapering or cessation of steroids may result in clinical and imaging relapses; close- and long-term follow-up for patients presenting this complication is warranted. MDPI 2023-01-07 /pmc/articles/PMC9863316/ /pubmed/36675425 http://dx.doi.org/10.3390/jcm12020496 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Bakola, Eleni
Papagiannopoulou, Georgia
Palaiodimou, Lina
Lagios, Konstantinos
Archontakis, Eftychios
Theodorou, Aikaterini
Katsanos, Aristeidis H.
Triantafyllou, Sokratis
Zouvelou, Vasiliki
Lachanis, Stefanos
Tzanetakos, Dimitrios
Tzartos, John S.
Giannopoulos, Sotirios
Tsivgoulis, Georgios
Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title_full Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title_fullStr Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title_full_unstemmed Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title_short Delayed Leucoencephalopathy as a Complication after Endovascular Therapy of Intracranial Aneurysms—A Case Series
title_sort delayed leucoencephalopathy as a complication after endovascular therapy of intracranial aneurysms—a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863316/
https://www.ncbi.nlm.nih.gov/pubmed/36675425
http://dx.doi.org/10.3390/jcm12020496
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