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Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women

The aim of this study was to determine the incidence of infections and cytological abnormalities and to investigate possible predisposing factors such as sociodemographic characteristics, sexual behavioral habits, and gynecological and obstetric backgrounds. Between 2013 and December 2016, a cross-s...

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Autores principales: Mangieri, Luis Fernando Lasaro, Cezar-dos-Santos, Fernando, Trugilo, Kleber Paiva, Watanabe, Maria Angelica Ehara, de Jaime Curti, Rafaela Roberta, Castilha, Eliza Pizarro, Moretto, Sarah Lott, Fernandes, Caroline Yukari Motoori, de Oliveira, Janaina Nicolau, de Oliveira, Karen Brajão
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863329/
https://www.ncbi.nlm.nih.gov/pubmed/36678496
http://dx.doi.org/10.3390/pathogens12010148
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author Mangieri, Luis Fernando Lasaro
Cezar-dos-Santos, Fernando
Trugilo, Kleber Paiva
Watanabe, Maria Angelica Ehara
de Jaime Curti, Rafaela Roberta
Castilha, Eliza Pizarro
Moretto, Sarah Lott
Fernandes, Caroline Yukari Motoori
de Oliveira, Janaina Nicolau
de Oliveira, Karen Brajão
author_facet Mangieri, Luis Fernando Lasaro
Cezar-dos-Santos, Fernando
Trugilo, Kleber Paiva
Watanabe, Maria Angelica Ehara
de Jaime Curti, Rafaela Roberta
Castilha, Eliza Pizarro
Moretto, Sarah Lott
Fernandes, Caroline Yukari Motoori
de Oliveira, Janaina Nicolau
de Oliveira, Karen Brajão
author_sort Mangieri, Luis Fernando Lasaro
collection PubMed
description The aim of this study was to determine the incidence of infections and cytological abnormalities and to investigate possible predisposing factors such as sociodemographic characteristics, sexual behavioral habits, and gynecological and obstetric backgrounds. Between 2013 and December 2016, a cross-sectional study was conducted among 429 consenting women, from whom cervical samples were tested for the presence of Human papillomavirus (HPV) by polymerase chain reaction (PCR). Susceptibility to HPV infection was assessed by binary logistic regression in light of possible predisposing factors, which were collected using a questionnaire. In our sample population, the prevalence of HPV infection was 49%; high-risk types had a higher prevalence of 89.1%. A larger proportion of HPV-infected women were under 25 years of age, were single, and had monthly incomes up to minimum wage. Multivariate binary logistic regression analysis showed that age younger than 25 years increased the odds of infection fivefold, while a monthly income of one to three minimum wages provided protection against HPV infection, even if the women were married or had a cohabiting partner. In the HPV-positive group, squamous intraepithelial lesions (SIL) occurred more frequently in women who earned up to one minimum wage monthly, but a monthly income of one to three minimum wages protected against the development of SIL. The results suggest that age, marital status, and monthly income are important cofactors for HPV infection and the development of SIL.
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spelling pubmed-98633292023-01-22 Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women Mangieri, Luis Fernando Lasaro Cezar-dos-Santos, Fernando Trugilo, Kleber Paiva Watanabe, Maria Angelica Ehara de Jaime Curti, Rafaela Roberta Castilha, Eliza Pizarro Moretto, Sarah Lott Fernandes, Caroline Yukari Motoori de Oliveira, Janaina Nicolau de Oliveira, Karen Brajão Pathogens Article The aim of this study was to determine the incidence of infections and cytological abnormalities and to investigate possible predisposing factors such as sociodemographic characteristics, sexual behavioral habits, and gynecological and obstetric backgrounds. Between 2013 and December 2016, a cross-sectional study was conducted among 429 consenting women, from whom cervical samples were tested for the presence of Human papillomavirus (HPV) by polymerase chain reaction (PCR). Susceptibility to HPV infection was assessed by binary logistic regression in light of possible predisposing factors, which were collected using a questionnaire. In our sample population, the prevalence of HPV infection was 49%; high-risk types had a higher prevalence of 89.1%. A larger proportion of HPV-infected women were under 25 years of age, were single, and had monthly incomes up to minimum wage. Multivariate binary logistic regression analysis showed that age younger than 25 years increased the odds of infection fivefold, while a monthly income of one to three minimum wages provided protection against HPV infection, even if the women were married or had a cohabiting partner. In the HPV-positive group, squamous intraepithelial lesions (SIL) occurred more frequently in women who earned up to one minimum wage monthly, but a monthly income of one to three minimum wages protected against the development of SIL. The results suggest that age, marital status, and monthly income are important cofactors for HPV infection and the development of SIL. MDPI 2023-01-16 /pmc/articles/PMC9863329/ /pubmed/36678496 http://dx.doi.org/10.3390/pathogens12010148 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mangieri, Luis Fernando Lasaro
Cezar-dos-Santos, Fernando
Trugilo, Kleber Paiva
Watanabe, Maria Angelica Ehara
de Jaime Curti, Rafaela Roberta
Castilha, Eliza Pizarro
Moretto, Sarah Lott
Fernandes, Caroline Yukari Motoori
de Oliveira, Janaina Nicolau
de Oliveira, Karen Brajão
Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title_full Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title_fullStr Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title_full_unstemmed Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title_short Cross-Sectional Analysis of Human Papillomavirus Infection and Cytological Abnormalities in Brazilian Women
title_sort cross-sectional analysis of human papillomavirus infection and cytological abnormalities in brazilian women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863329/
https://www.ncbi.nlm.nih.gov/pubmed/36678496
http://dx.doi.org/10.3390/pathogens12010148
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