N-Acetyl-l-phenylalanine Racemization during TBTU Amidation: An In-Depth Study for the Synthesis of Anti-Inflammatory 2-(N-Acetyl)-l-phenylalanylamido-2-deoxy-d-glucose (NAPA)

A thorough study on the amidation conditions of N-acetyl-l-phenylalanine using TBTU and various bases is reported for the synthesis of 2-(N-acetyl)-l-phenylalanylamido-2-deoxy-d-glucose (NAPA), a promising drug for the treatment of joints diseases. TBTU-mediated diastereoselective amidation reaction...

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Detalles Bibliográficos
Autores principales: Sturabotti, Elisa, Vetica, Fabrizio, Toscano, Giorgia, Calcaterra, Andrea, Martinelli, Andrea, Migneco, Luisa Maria, Leonelli, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863357/
https://www.ncbi.nlm.nih.gov/pubmed/36677671
http://dx.doi.org/10.3390/molecules28020581

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