Cargando…

Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease

Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4)...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Weizhao, Liu, Mengchen, Wu, Xixin, Meng, Shandong, Yu, Kanghui, Su, Huanhuan, Liang, Quanhai, Chen, Feng, Li, Jincheng, Xiao, Wenqin, Ling, Huangsheng, Wu, Yunfan, Jiang, Guihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863421/
https://www.ncbi.nlm.nih.gov/pubmed/36675803
http://dx.doi.org/10.3390/jpm13010142
_version_ 1784875330136178688
author Lin, Weizhao
Liu, Mengchen
Wu, Xixin
Meng, Shandong
Yu, Kanghui
Su, Huanhuan
Liang, Quanhai
Chen, Feng
Li, Jincheng
Xiao, Wenqin
Ling, Huangsheng
Wu, Yunfan
Jiang, Guihua
author_facet Lin, Weizhao
Liu, Mengchen
Wu, Xixin
Meng, Shandong
Yu, Kanghui
Su, Huanhuan
Liang, Quanhai
Chen, Feng
Li, Jincheng
Xiao, Wenqin
Ling, Huangsheng
Wu, Yunfan
Jiang, Guihua
author_sort Lin, Weizhao
collection PubMed
description Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4) and 31 healthy controls (HCs). For CKD patients, we also obtained laboratory results as well as neuropsychological tests. We conducted brain perfusion imaging studies using arterial spin labeling and calculated the relationship between regional CBF changes and various clinical indicators and neuropsychological tests. We also generated receiver operator characteristic (ROC) curves to explore whether CBF value changes in certain brain regions can be used to identify CKD. Results: Compared with HCs, CBF decreased in the right insula and increased in the left hippocampus in the CKD4 group; through partial correlation analysis, we found that CBF in the right insula was negatively correlated with the number connection test A (NCT-A) (r = −0.544, p = 0.024); CBF in the left hippocampus was positively correlated with blood urea nitrogen (r = 0.649, p = 0.005) and negatively correlated with serum calcium level (r = −0.646, p = 0.005). By comparing the ROC curve area, it demonstrated that altered CBF values in the right insula (AUC = 0.861, p < 0.01) and left hippocampus (AUC = 0.862, p < 0.01) have a good ability to identify CKD. Conclusions: Our study found that CBF alterations in the left hippocampus and the right insula brain of adult patients with stage 4 CKD were correlated with disease severity or laboratory indicators. These findings provide further insight into the relationship between altered cerebral perfusion and cognitive impairment in patients with non-end-stage CKD as well as, additional information the underlying neuropathophysiological mechanisms.
format Online
Article
Text
id pubmed-9863421
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98634212023-01-22 Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease Lin, Weizhao Liu, Mengchen Wu, Xixin Meng, Shandong Yu, Kanghui Su, Huanhuan Liang, Quanhai Chen, Feng Li, Jincheng Xiao, Wenqin Ling, Huangsheng Wu, Yunfan Jiang, Guihua J Pers Med Article Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4) and 31 healthy controls (HCs). For CKD patients, we also obtained laboratory results as well as neuropsychological tests. We conducted brain perfusion imaging studies using arterial spin labeling and calculated the relationship between regional CBF changes and various clinical indicators and neuropsychological tests. We also generated receiver operator characteristic (ROC) curves to explore whether CBF value changes in certain brain regions can be used to identify CKD. Results: Compared with HCs, CBF decreased in the right insula and increased in the left hippocampus in the CKD4 group; through partial correlation analysis, we found that CBF in the right insula was negatively correlated with the number connection test A (NCT-A) (r = −0.544, p = 0.024); CBF in the left hippocampus was positively correlated with blood urea nitrogen (r = 0.649, p = 0.005) and negatively correlated with serum calcium level (r = −0.646, p = 0.005). By comparing the ROC curve area, it demonstrated that altered CBF values in the right insula (AUC = 0.861, p < 0.01) and left hippocampus (AUC = 0.862, p < 0.01) have a good ability to identify CKD. Conclusions: Our study found that CBF alterations in the left hippocampus and the right insula brain of adult patients with stage 4 CKD were correlated with disease severity or laboratory indicators. These findings provide further insight into the relationship between altered cerebral perfusion and cognitive impairment in patients with non-end-stage CKD as well as, additional information the underlying neuropathophysiological mechanisms. MDPI 2023-01-11 /pmc/articles/PMC9863421/ /pubmed/36675803 http://dx.doi.org/10.3390/jpm13010142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Weizhao
Liu, Mengchen
Wu, Xixin
Meng, Shandong
Yu, Kanghui
Su, Huanhuan
Liang, Quanhai
Chen, Feng
Li, Jincheng
Xiao, Wenqin
Ling, Huangsheng
Wu, Yunfan
Jiang, Guihua
Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title_full Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title_fullStr Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title_full_unstemmed Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title_short Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
title_sort altered cerebral blood flow in the progression of chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863421/
https://www.ncbi.nlm.nih.gov/pubmed/36675803
http://dx.doi.org/10.3390/jpm13010142
work_keys_str_mv AT linweizhao alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT liumengchen alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT wuxixin alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT mengshandong alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT yukanghui alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT suhuanhuan alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT liangquanhai alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT chenfeng alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT lijincheng alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT xiaowenqin alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT linghuangsheng alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT wuyunfan alteredcerebralbloodflowintheprogressionofchronickidneydisease
AT jiangguihua alteredcerebralbloodflowintheprogressionofchronickidneydisease