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Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease
Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4)...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863421/ https://www.ncbi.nlm.nih.gov/pubmed/36675803 http://dx.doi.org/10.3390/jpm13010142 |
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author | Lin, Weizhao Liu, Mengchen Wu, Xixin Meng, Shandong Yu, Kanghui Su, Huanhuan Liang, Quanhai Chen, Feng Li, Jincheng Xiao, Wenqin Ling, Huangsheng Wu, Yunfan Jiang, Guihua |
author_facet | Lin, Weizhao Liu, Mengchen Wu, Xixin Meng, Shandong Yu, Kanghui Su, Huanhuan Liang, Quanhai Chen, Feng Li, Jincheng Xiao, Wenqin Ling, Huangsheng Wu, Yunfan Jiang, Guihua |
author_sort | Lin, Weizhao |
collection | PubMed |
description | Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4) and 31 healthy controls (HCs). For CKD patients, we also obtained laboratory results as well as neuropsychological tests. We conducted brain perfusion imaging studies using arterial spin labeling and calculated the relationship between regional CBF changes and various clinical indicators and neuropsychological tests. We also generated receiver operator characteristic (ROC) curves to explore whether CBF value changes in certain brain regions can be used to identify CKD. Results: Compared with HCs, CBF decreased in the right insula and increased in the left hippocampus in the CKD4 group; through partial correlation analysis, we found that CBF in the right insula was negatively correlated with the number connection test A (NCT-A) (r = −0.544, p = 0.024); CBF in the left hippocampus was positively correlated with blood urea nitrogen (r = 0.649, p = 0.005) and negatively correlated with serum calcium level (r = −0.646, p = 0.005). By comparing the ROC curve area, it demonstrated that altered CBF values in the right insula (AUC = 0.861, p < 0.01) and left hippocampus (AUC = 0.862, p < 0.01) have a good ability to identify CKD. Conclusions: Our study found that CBF alterations in the left hippocampus and the right insula brain of adult patients with stage 4 CKD were correlated with disease severity or laboratory indicators. These findings provide further insight into the relationship between altered cerebral perfusion and cognitive impairment in patients with non-end-stage CKD as well as, additional information the underlying neuropathophysiological mechanisms. |
format | Online Article Text |
id | pubmed-9863421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98634212023-01-22 Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease Lin, Weizhao Liu, Mengchen Wu, Xixin Meng, Shandong Yu, Kanghui Su, Huanhuan Liang, Quanhai Chen, Feng Li, Jincheng Xiao, Wenqin Ling, Huangsheng Wu, Yunfan Jiang, Guihua J Pers Med Article Background: In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known. Methods: Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4) and 31 healthy controls (HCs). For CKD patients, we also obtained laboratory results as well as neuropsychological tests. We conducted brain perfusion imaging studies using arterial spin labeling and calculated the relationship between regional CBF changes and various clinical indicators and neuropsychological tests. We also generated receiver operator characteristic (ROC) curves to explore whether CBF value changes in certain brain regions can be used to identify CKD. Results: Compared with HCs, CBF decreased in the right insula and increased in the left hippocampus in the CKD4 group; through partial correlation analysis, we found that CBF in the right insula was negatively correlated with the number connection test A (NCT-A) (r = −0.544, p = 0.024); CBF in the left hippocampus was positively correlated with blood urea nitrogen (r = 0.649, p = 0.005) and negatively correlated with serum calcium level (r = −0.646, p = 0.005). By comparing the ROC curve area, it demonstrated that altered CBF values in the right insula (AUC = 0.861, p < 0.01) and left hippocampus (AUC = 0.862, p < 0.01) have a good ability to identify CKD. Conclusions: Our study found that CBF alterations in the left hippocampus and the right insula brain of adult patients with stage 4 CKD were correlated with disease severity or laboratory indicators. These findings provide further insight into the relationship between altered cerebral perfusion and cognitive impairment in patients with non-end-stage CKD as well as, additional information the underlying neuropathophysiological mechanisms. MDPI 2023-01-11 /pmc/articles/PMC9863421/ /pubmed/36675803 http://dx.doi.org/10.3390/jpm13010142 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Weizhao Liu, Mengchen Wu, Xixin Meng, Shandong Yu, Kanghui Su, Huanhuan Liang, Quanhai Chen, Feng Li, Jincheng Xiao, Wenqin Ling, Huangsheng Wu, Yunfan Jiang, Guihua Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title | Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title_full | Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title_fullStr | Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title_full_unstemmed | Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title_short | Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease |
title_sort | altered cerebral blood flow in the progression of chronic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863421/ https://www.ncbi.nlm.nih.gov/pubmed/36675803 http://dx.doi.org/10.3390/jpm13010142 |
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