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The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)

Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H(2)O(2), can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing...

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Detalles Bibliográficos
Autores principales: Ibáñez Gaspar, Verónica, McMorrow, Tara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863498/
https://www.ncbi.nlm.nih.gov/pubmed/36674555
http://dx.doi.org/10.3390/ijms24021043
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author Ibáñez Gaspar, Verónica
McMorrow, Tara
author_facet Ibáñez Gaspar, Verónica
McMorrow, Tara
author_sort Ibáñez Gaspar, Verónica
collection PubMed
description Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H(2)O(2), can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing the degradation of the extracellular matrix, an increase in the ROS H(2)O(2) might have an impact on MMP-2/MMP-9 activity. The natural compound curcumin has shown some anticancer effects, although its bioavailability hinders its therapeutic potential. However, curcumin and its analogues were shown to resensitize kidney cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. This study shows that the curcuminoid EF24 in combination with TRAIL increases peroxidase activity in the renal adenocarcinoma cell line ACHN, reducing the level of intracellular H(2)O(2) and MMP-2/MMP-9 activity, a mechanism that is also observed after treatment with curcumin and TRAIL.
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spelling pubmed-98634982023-01-22 The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2) Ibáñez Gaspar, Verónica McMorrow, Tara Int J Mol Sci Article Cancer cells present high levels of oxidative stress, and although an increase in reactive oxygen species (ROS), such as H(2)O(2), can lead to apoptosis, it can also induce cell invasion and metastasis. As the increase in ROS can lead to an increase in the expression of MMP-2 and MMP-9, thus causing the degradation of the extracellular matrix, an increase in the ROS H(2)O(2) might have an impact on MMP-2/MMP-9 activity. The natural compound curcumin has shown some anticancer effects, although its bioavailability hinders its therapeutic potential. However, curcumin and its analogues were shown to resensitize kidney cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. This study shows that the curcuminoid EF24 in combination with TRAIL increases peroxidase activity in the renal adenocarcinoma cell line ACHN, reducing the level of intracellular H(2)O(2) and MMP-2/MMP-9 activity, a mechanism that is also observed after treatment with curcumin and TRAIL. MDPI 2023-01-05 /pmc/articles/PMC9863498/ /pubmed/36674555 http://dx.doi.org/10.3390/ijms24021043 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ibáñez Gaspar, Verónica
McMorrow, Tara
The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title_full The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title_fullStr The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title_full_unstemmed The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title_short The Curcuminoid EF24 in Combination with TRAIL Reduces Human Renal Cancer Cell Migration by Decreasing MMP-2/MMP-9 Activity through a Reduction in H(2)O(2)
title_sort curcuminoid ef24 in combination with trail reduces human renal cancer cell migration by decreasing mmp-2/mmp-9 activity through a reduction in h(2)o(2)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863498/
https://www.ncbi.nlm.nih.gov/pubmed/36674555
http://dx.doi.org/10.3390/ijms24021043
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