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The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Altera...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863528/ https://www.ncbi.nlm.nih.gov/pubmed/36677054 http://dx.doi.org/10.3390/metabo13010129 |
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author | Mukherjee, Anirban Goutam Wanjari, Uddesh Ramesh Kannampuzha, Sandra Murali, Reshma Namachivayam, Arunraj Ganesan, Raja Dey, Abhijit Babu, Achsha Renu, Kaviyarasi Vellingiri, Balachandar Ramanathan, Gnanasambandan Priya Doss C., George Elsherbiny, Nehal Elsherbini, Amira M. Alsamman, Alsamman M. Zayed, Hatem Gopalakrishnan, Abilash Valsala |
author_facet | Mukherjee, Anirban Goutam Wanjari, Uddesh Ramesh Kannampuzha, Sandra Murali, Reshma Namachivayam, Arunraj Ganesan, Raja Dey, Abhijit Babu, Achsha Renu, Kaviyarasi Vellingiri, Balachandar Ramanathan, Gnanasambandan Priya Doss C., George Elsherbiny, Nehal Elsherbini, Amira M. Alsamman, Alsamman M. Zayed, Hatem Gopalakrishnan, Abilash Valsala |
author_sort | Mukherjee, Anirban Goutam |
collection | PubMed |
description | As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it. |
format | Online Article Text |
id | pubmed-9863528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98635282023-01-22 The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review Mukherjee, Anirban Goutam Wanjari, Uddesh Ramesh Kannampuzha, Sandra Murali, Reshma Namachivayam, Arunraj Ganesan, Raja Dey, Abhijit Babu, Achsha Renu, Kaviyarasi Vellingiri, Balachandar Ramanathan, Gnanasambandan Priya Doss C., George Elsherbiny, Nehal Elsherbini, Amira M. Alsamman, Alsamman M. Zayed, Hatem Gopalakrishnan, Abilash Valsala Metabolites Review As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, and infertility. No one knows what causes it or how to stop it yet. Alterations in gut microbiota composition and disruptions in secondary bile acid production appear to play a causative role in developing PCOS. PCOS pathophysiology and phenotypes are tightly related to both enteric and vaginal bacteria. Patients with PCOS exhibit changed microbiome compositions and decreased microbial diversity. Intestinal microorganisms also alter PCOS patient phenotypes by upregulating or downregulating hormone release, gut-brain mediators, and metabolite synthesis. The human body’s gut microbiota, also known as the “second genome,” can interact with the environment to improve metabolic and immunological function. Inflammation is connected to PCOS and may be caused by dysbiosis in the gut microbiome. This review sheds light on the recently discovered connections between gut microbiota and insulin resistance (IR) and the potential mechanisms of PCOS. This study also describes metabolomic studies to obtain a clear view of PCOS and ways to tackle it. MDPI 2023-01-14 /pmc/articles/PMC9863528/ /pubmed/36677054 http://dx.doi.org/10.3390/metabo13010129 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mukherjee, Anirban Goutam Wanjari, Uddesh Ramesh Kannampuzha, Sandra Murali, Reshma Namachivayam, Arunraj Ganesan, Raja Dey, Abhijit Babu, Achsha Renu, Kaviyarasi Vellingiri, Balachandar Ramanathan, Gnanasambandan Priya Doss C., George Elsherbiny, Nehal Elsherbini, Amira M. Alsamman, Alsamman M. Zayed, Hatem Gopalakrishnan, Abilash Valsala The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title_full | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title_fullStr | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title_full_unstemmed | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title_short | The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review |
title_sort | implication of mechanistic approaches and the role of the microbiome in polycystic ovary syndrome (pcos): a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863528/ https://www.ncbi.nlm.nih.gov/pubmed/36677054 http://dx.doi.org/10.3390/metabo13010129 |
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