Cargando…

ProNGF Expression and Targeting in Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is the most lethal adult brain cancer. Temozolomide (TMZ), the standard chemotherapeutic drug used in GBM, has limited benefit and alternate therapies are needed to improve GBM treatment. Nerve growth factor (NGF) and its precursor proNGF are increasingly recognized as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marsland, Mark, Dowdell, Amiee, Faulkner, Sam, Jobling, Phillip, Rush, Robert A., Gedye, Craig, Lynam, James, Griffin, Cassandra P., Baker, Mark, Marsland, Joanne, Jiang, Chen Chen, Hondermarck, Hubert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863529/ https://www.ncbi.nlm.nih.gov/pubmed/36675126 http://dx.doi.org/10.3390/ijms24021616

Ejemplares similares

Expression of NGF/proNGF and Their Receptors TrkA, p75(NTR) and Sortilin in Melanoma
por: Marsland, Mark, et al.
Publicado: (2022)

The Membrane Protein Sortilin Is a Potential Biomarker and Target for Glioblastoma
por: Marsland, Mark, et al.
Publicado: (2023)

Targeting XBP1 mRNA splicing sensitizes glioblastoma to chemotherapy
por: Dowdell, Amiee, et al.
Publicado: (2023)

ProNGF is a potential diagnostic biomarker for thyroid cancer
por: Faulkner, Sam, et al.
Publicado: (2016)

The Precursor for Nerve Growth Factor (proNGF) in Thyroid Cancer Lymph Node Metastases: Correlation with Primary Tumour and Pathological Variables
por: Rowe, Christopher W., et al.
Publicado: (2019)

The precursor for nerve growth factor (proNGF) is not a serum or biopsy-rinse biomarker for thyroid cancer diagnosis
por: Rowe, Christopher W., et al.
Publicado: (2019)

Conformational Plasticity of proNGF
por: Paoletti, Francesca, et al.
Publicado: (2011)

ProNGF and Neurodegeneration in Alzheimer’s Disease
por: Fahnestock, Margaret, et al.
Publicado: (2019)

An Optimized Procedure for the Site-Directed Labeling of NGF and proNGF for Imaging Purposes
por: Di Matteo, Pierluigi, et al.
Publicado: (2017)

Influence of Quadrato Motor Training on Salivary proNGF and proBDNF
por: Caserta, Micaela, et al.
Publicado: (2019)

NGF and proNGF Reciprocal Interference in Immunoassays: Open Questions, Criticalities, and Ways Forward
por: Malerba, Francesca, et al.
Publicado: (2016)

proNGF Involvement in the Adult Neurogenesis Dysfunction in Alzheimer’s Disease
por: Olabiyi, Bolanle Fatimat, et al.
Publicado: (2021)

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75(NTR)
por: Kropf, Erika, et al.
Publicado: (2023)

p75(NTR), but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
por: VonDran, Melissa W., et al.
Publicado: (2014)

proNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces
por: Arisi, Ivan, et al.
Publicado: (2014)

ProNGF, but Not NGF, Switches from Neurotrophic to Apoptotic Activity in Response to Reductions in TrkA Receptor Levels
por: Ioannou, Maria S., et al.
Publicado: (2017)

Development of a Cell-Based Assay to Assess Binding of the proNGF Prodomain to Sortilin
por: Malik, Ibrahim, et al.
Publicado: (2017)

NGF and proNGF Regulate Functionally Distinct mRNAs in PC12 Cells: An Early Gene Expression Profiling
por: D'Onofrio, Mara, et al.
Publicado: (2011)

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway
por: Al-Gayyar, Mohammed M. H., et al.
Publicado: (2013)

Creating Well-Being: Increased Creativity and proNGF Decrease following Quadrato Motor Training
por: Venditti, Sabrina, et al.
Publicado: (2015)

ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism
por: Howard, Laura, et al.
Publicado: (2013)

Oxidative DNA damage triggers ProNGF-Mediated apoptosis in the striatum of 6-OHDA-treated rats
por: Wang, Tao, et al.
Publicado: (2012)

Correction: Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway
Publicado: (2014)

Retraction: Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway
Publicado: (2017)

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a “Painless” Lead Investigational Candidate for Therapeutic Applications
por: Malerba, Francesca, et al.
Publicado: (2015)

The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
por: Griffin, Nathan, et al.
Publicado: (2020)

The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung
por: Gao, Fangfang, et al.
Publicado: (2018)

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
por: Siao, Chia-Jen, et al.
Publicado: (2012)

Tumor innervation and clinical outcome in pancreatic cancer
por: Ferdoushi, Aysha, et al.
Publicado: (2021)

ProNGF derived from rat sciatic nerves downregulates neurite elongation and axon specification in PC12 cells
por: Trigos, Anna Sofía, et al.
Publicado: (2015)

ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice
por: Fasulo, Luisa, et al.
Publicado: (2017)

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy
por: Barcelona, Pablo F., et al.
Publicado: (2018)

Effects of Reactive Oxygen and Nitrogen Species on TrkA Expression and Signalling: Implications for proNGF in Aging and Alzheimer’s Disease
por: Kropf, Erika, et al.
Publicado: (2021)

A Single Session of Whole-Body Electromyostimulation Increases Muscle Strength, Endurance and proNGF in Early Parkinson Patients
por: Fiorilli, Giovanni, et al.
Publicado: (2021)

Presence of proNGF-Sortilin Signaling Complex in Nigral Dopamine Neurons and Its Variation in Relation to Aging, Lactacystin and 6-OHDA Insults
por: Xia, Yi, et al.
Publicado: (2013)

ProNGF/NGF Modulates Autophagy and Apoptosis through PI3K/Akt/mTOR and ERK Signaling Pathways following Cerebral Ischemia-Reperfusion in Rats
por: Li, Yanbo, et al.
Publicado: (2022)

The NGF R100W Mutation, Associated with Hereditary Sensory Autonomic Neuropathy Type V, Specifically Affects the Binding Energetic Landscapes of NGF and of Its Precursor proNGF and p75NTR
por: Covaceuszach, Sonia, et al.
Publicado: (2023)

Silencing p75(NTR) prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina
por: Shanab, Ahmed Y, et al.
Publicado: (2015)

Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels
por: Li, Ang, et al.
Publicado: (2021)

Postmortem brain donations vs premortem surgical resections for glioblastoma research: viewing the matter as a whole
por: Griffin, Cassandra P, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e93rt9fj8lflnqd8pnlceb21j1