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Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy

Little is known about the use of intranasal vaccines, but some studies have shown that this innovative way of administration is preferred over needle injection as it is considered both less painful and intrusive to the body, equally effective, and associated with fewer side effects. This study aimed...

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Autores principales: Boragno, Paola, Fiabane, Elena, Colledani, Daiana, Dalla Gasperina, Daniela, Setti, Ilaria, Sommovigo, Valentina, Gabanelli, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863592/
https://www.ncbi.nlm.nih.gov/pubmed/36679983
http://dx.doi.org/10.3390/vaccines11010138
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author Boragno, Paola
Fiabane, Elena
Colledani, Daiana
Dalla Gasperina, Daniela
Setti, Ilaria
Sommovigo, Valentina
Gabanelli, Paola
author_facet Boragno, Paola
Fiabane, Elena
Colledani, Daiana
Dalla Gasperina, Daniela
Setti, Ilaria
Sommovigo, Valentina
Gabanelli, Paola
author_sort Boragno, Paola
collection PubMed
description Little is known about the use of intranasal vaccines, but some studies have shown that this innovative way of administration is preferred over needle injection as it is considered both less painful and intrusive to the body, equally effective, and associated with fewer side effects. This study aimed to investigate specific psychological determinants (intolerance of uncertainty, persecutory ideation, perceived control, vaccine hesitancy) of attitude toward nasal vaccine delivery. A convenience sample including 700 Italian participants took part in this cross-sectional study and completed an online questionnaire. A structural equation model with a latent variable was performed to study the relationship between psychological variables, vaccine hesitancy, and attitude toward nasal vaccine delivery. The results indicate that both a hesitant attitude toward vaccination (β = 0.20, p = 0.000) and low perceived control (β = −0.20, p = 0.005) may directly increase preference for nasal administration; furthermore, high levels of persecutory ideation may indirectly influence the propensity for intranasal vaccine. These findings suggest that pharmaceutical companies could implement nasal vaccines and provide detailed information on these vaccines through informational campaigns. Hesitant individuals with low levels of perceived control could more easily comply with these types of vaccines.
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spelling pubmed-98635922023-01-22 Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy Boragno, Paola Fiabane, Elena Colledani, Daiana Dalla Gasperina, Daniela Setti, Ilaria Sommovigo, Valentina Gabanelli, Paola Vaccines (Basel) Article Little is known about the use of intranasal vaccines, but some studies have shown that this innovative way of administration is preferred over needle injection as it is considered both less painful and intrusive to the body, equally effective, and associated with fewer side effects. This study aimed to investigate specific psychological determinants (intolerance of uncertainty, persecutory ideation, perceived control, vaccine hesitancy) of attitude toward nasal vaccine delivery. A convenience sample including 700 Italian participants took part in this cross-sectional study and completed an online questionnaire. A structural equation model with a latent variable was performed to study the relationship between psychological variables, vaccine hesitancy, and attitude toward nasal vaccine delivery. The results indicate that both a hesitant attitude toward vaccination (β = 0.20, p = 0.000) and low perceived control (β = −0.20, p = 0.005) may directly increase preference for nasal administration; furthermore, high levels of persecutory ideation may indirectly influence the propensity for intranasal vaccine. These findings suggest that pharmaceutical companies could implement nasal vaccines and provide detailed information on these vaccines through informational campaigns. Hesitant individuals with low levels of perceived control could more easily comply with these types of vaccines. MDPI 2023-01-07 /pmc/articles/PMC9863592/ /pubmed/36679983 http://dx.doi.org/10.3390/vaccines11010138 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boragno, Paola
Fiabane, Elena
Colledani, Daiana
Dalla Gasperina, Daniela
Setti, Ilaria
Sommovigo, Valentina
Gabanelli, Paola
Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title_full Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title_fullStr Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title_full_unstemmed Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title_short Attitude towards Intranasal Vaccines and Psychological Determinants: Effects on the General Population in Northern Italy
title_sort attitude towards intranasal vaccines and psychological determinants: effects on the general population in northern italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863592/
https://www.ncbi.nlm.nih.gov/pubmed/36679983
http://dx.doi.org/10.3390/vaccines11010138
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