A Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD

CAD is a 1.5 MDa hexameric protein with four enzymatic domains responsible for initiating de novo biosynthesis of pyrimidines nucleotides: glutaminase, carbamoyl phosphate synthetase, aspartate transcarbamoylase (ATC), and dihydroorotase. Despite its central metabolic role and implication in cancer...

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Detalles Bibliográficos
Autores principales: del Caño-Ochoa, Francisco, Rubio-del-Campo, Antonio, Ramón-Maiques, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863657/
https://www.ncbi.nlm.nih.gov/pubmed/36677714
http://dx.doi.org/10.3390/molecules28020660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863657/
https://www.ncbi.nlm.nih.gov/pubmed/36677714
http://dx.doi.org/10.3390/molecules28020660

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