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Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study

Purpose: This study aimed to summarize and analyze the clinical data of intestinal tuberculosis (ITB) in order to provide guidance for accurate diagnosis and treatment of ITB. Methods: This study consecutively included patients with ITB who were admitted to our hospital from 2008 to 2021 and retrosp...

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Autores principales: Zeng, Jiaqi, Zhou, Guanzhou, Pan, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863723/
https://www.ncbi.nlm.nih.gov/pubmed/36675374
http://dx.doi.org/10.3390/jcm12020445
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author Zeng, Jiaqi
Zhou, Guanzhou
Pan, Fei
author_facet Zeng, Jiaqi
Zhou, Guanzhou
Pan, Fei
author_sort Zeng, Jiaqi
collection PubMed
description Purpose: This study aimed to summarize and analyze the clinical data of intestinal tuberculosis (ITB) in order to provide guidance for accurate diagnosis and treatment of ITB. Methods: This study consecutively included patients with ITB who were admitted to our hospital from 2008 to 2021 and retrospectively analyzed their clinical features. Results: Forty-six patients were included. The most common clinical symptom was weight loss (67.4%). Seventy percent of 20 patients were positive for tuberculin skin test; 57.1% of 14 patients were positive for mycobacterium tuberculosis specific cellular immune response test, while 84.6% of 26 patients were positive for tuberculosis infection T cell spot test. By chest computed tomography (CT) examination, 25% and 5.6% of 36 patients were diagnosed with active pulmonary tuberculosis and with inactive pulmonary tuberculosis, respectively. By abdominal CT examination, the most common sign was abdominal lymph node enlargement (43.2%). Forty-two patients underwent colonoscopy, and the most common endoscopic manifestation was ileocecal ulcer (59.5%), followed by colonic ulcer (35.7%) and ileocecal valve deformity (26.2%). ITB most frequently involved the terminal ileum/ileocecal region (76.1%). Granulomatous inflammation with multinucleated giant cells and caseous necrosis was found via endoscopic biopsies, the ultrasound-guided percutaneous biopsy of enlarged mesentery lymph nodes, and surgical interventions. The acid-fast bacilli were discovered in 53.1% of 32 samples. Twenty-one cases highly suspected of ITB were confirmed after responding to empiric anti-tuberculosis therapy. Conclusions: It was necessary to comprehensively analyze clinical features to make an accurate diagnosis of ITB and aid in distinguishing ITB from diseases such as Crohn’s disease and malignant tumors.
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spelling pubmed-98637232023-01-22 Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study Zeng, Jiaqi Zhou, Guanzhou Pan, Fei J Clin Med Article Purpose: This study aimed to summarize and analyze the clinical data of intestinal tuberculosis (ITB) in order to provide guidance for accurate diagnosis and treatment of ITB. Methods: This study consecutively included patients with ITB who were admitted to our hospital from 2008 to 2021 and retrospectively analyzed their clinical features. Results: Forty-six patients were included. The most common clinical symptom was weight loss (67.4%). Seventy percent of 20 patients were positive for tuberculin skin test; 57.1% of 14 patients were positive for mycobacterium tuberculosis specific cellular immune response test, while 84.6% of 26 patients were positive for tuberculosis infection T cell spot test. By chest computed tomography (CT) examination, 25% and 5.6% of 36 patients were diagnosed with active pulmonary tuberculosis and with inactive pulmonary tuberculosis, respectively. By abdominal CT examination, the most common sign was abdominal lymph node enlargement (43.2%). Forty-two patients underwent colonoscopy, and the most common endoscopic manifestation was ileocecal ulcer (59.5%), followed by colonic ulcer (35.7%) and ileocecal valve deformity (26.2%). ITB most frequently involved the terminal ileum/ileocecal region (76.1%). Granulomatous inflammation with multinucleated giant cells and caseous necrosis was found via endoscopic biopsies, the ultrasound-guided percutaneous biopsy of enlarged mesentery lymph nodes, and surgical interventions. The acid-fast bacilli were discovered in 53.1% of 32 samples. Twenty-one cases highly suspected of ITB were confirmed after responding to empiric anti-tuberculosis therapy. Conclusions: It was necessary to comprehensively analyze clinical features to make an accurate diagnosis of ITB and aid in distinguishing ITB from diseases such as Crohn’s disease and malignant tumors. MDPI 2023-01-05 /pmc/articles/PMC9863723/ /pubmed/36675374 http://dx.doi.org/10.3390/jcm12020445 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zeng, Jiaqi
Zhou, Guanzhou
Pan, Fei
Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title_full Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title_fullStr Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title_full_unstemmed Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title_short Clinical Analysis of Intestinal Tuberculosis: A Retrospective Study
title_sort clinical analysis of intestinal tuberculosis: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863723/
https://www.ncbi.nlm.nih.gov/pubmed/36675374
http://dx.doi.org/10.3390/jcm12020445
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