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Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challeng...

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Autores principales: Peng, Bo, Zhang, Si-Yuan, Chan, Ka Iong, Zhong, Zhang-Feng, Wang, Yi-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863744/
https://www.ncbi.nlm.nih.gov/pubmed/36677797
http://dx.doi.org/10.3390/molecules28020740
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author Peng, Bo
Zhang, Si-Yuan
Chan, Ka Iong
Zhong, Zhang-Feng
Wang, Yi-Tao
author_facet Peng, Bo
Zhang, Si-Yuan
Chan, Ka Iong
Zhong, Zhang-Feng
Wang, Yi-Tao
author_sort Peng, Bo
collection PubMed
description Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challenges for the treatment of breast cancer. Adenosine 5′-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming and reverse the “Warburg effect” via multiple metabolic signaling pathways in breast cancer. Previous studies suggest that the activation of AMPK suppresses the growth and metastasis of breast cancer cells, as well as stimulating the responses of immune cells. However, some other reports claim that the development and poor prognosis of breast cancer are related to the overexpression and aberrant activation of AMPK. Thus, the role of AMPK in the progression of breast cancer is still controversial. In this review, we summarize the current understanding of AMPK, particularly the comprehensive bidirectional functions of AMPK in cancer progression; discuss the pharmacological activators of AMPK and some specific molecules, including the natural products (including berberine, curcumin, (−)-epigallocatechin-3-gallate, ginsenosides, and paclitaxel) that influence the efficacy of these activators in cancer therapy; and elaborate the role of AMPK as a potential therapeutic target for the treatment of breast cancer.
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spelling pubmed-98637442023-01-22 Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer Peng, Bo Zhang, Si-Yuan Chan, Ka Iong Zhong, Zhang-Feng Wang, Yi-Tao Molecules Review Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challenges for the treatment of breast cancer. Adenosine 5′-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming and reverse the “Warburg effect” via multiple metabolic signaling pathways in breast cancer. Previous studies suggest that the activation of AMPK suppresses the growth and metastasis of breast cancer cells, as well as stimulating the responses of immune cells. However, some other reports claim that the development and poor prognosis of breast cancer are related to the overexpression and aberrant activation of AMPK. Thus, the role of AMPK in the progression of breast cancer is still controversial. In this review, we summarize the current understanding of AMPK, particularly the comprehensive bidirectional functions of AMPK in cancer progression; discuss the pharmacological activators of AMPK and some specific molecules, including the natural products (including berberine, curcumin, (−)-epigallocatechin-3-gallate, ginsenosides, and paclitaxel) that influence the efficacy of these activators in cancer therapy; and elaborate the role of AMPK as a potential therapeutic target for the treatment of breast cancer. MDPI 2023-01-11 /pmc/articles/PMC9863744/ /pubmed/36677797 http://dx.doi.org/10.3390/molecules28020740 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peng, Bo
Zhang, Si-Yuan
Chan, Ka Iong
Zhong, Zhang-Feng
Wang, Yi-Tao
Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title_full Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title_fullStr Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title_full_unstemmed Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title_short Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
title_sort novel anti-cancer products targeting ampk: natural herbal medicine against breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863744/
https://www.ncbi.nlm.nih.gov/pubmed/36677797
http://dx.doi.org/10.3390/molecules28020740
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