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Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer
Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challeng...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863744/ https://www.ncbi.nlm.nih.gov/pubmed/36677797 http://dx.doi.org/10.3390/molecules28020740 |
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author | Peng, Bo Zhang, Si-Yuan Chan, Ka Iong Zhong, Zhang-Feng Wang, Yi-Tao |
author_facet | Peng, Bo Zhang, Si-Yuan Chan, Ka Iong Zhong, Zhang-Feng Wang, Yi-Tao |
author_sort | Peng, Bo |
collection | PubMed |
description | Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challenges for the treatment of breast cancer. Adenosine 5′-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming and reverse the “Warburg effect” via multiple metabolic signaling pathways in breast cancer. Previous studies suggest that the activation of AMPK suppresses the growth and metastasis of breast cancer cells, as well as stimulating the responses of immune cells. However, some other reports claim that the development and poor prognosis of breast cancer are related to the overexpression and aberrant activation of AMPK. Thus, the role of AMPK in the progression of breast cancer is still controversial. In this review, we summarize the current understanding of AMPK, particularly the comprehensive bidirectional functions of AMPK in cancer progression; discuss the pharmacological activators of AMPK and some specific molecules, including the natural products (including berberine, curcumin, (−)-epigallocatechin-3-gallate, ginsenosides, and paclitaxel) that influence the efficacy of these activators in cancer therapy; and elaborate the role of AMPK as a potential therapeutic target for the treatment of breast cancer. |
format | Online Article Text |
id | pubmed-9863744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98637442023-01-22 Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer Peng, Bo Zhang, Si-Yuan Chan, Ka Iong Zhong, Zhang-Feng Wang, Yi-Tao Molecules Review Breast cancer is a common cancer in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast cancer and cancer metastasis, but abnormal metabolism, immunosuppression, and multidrug resistance involving multiple regulators remain the major challenges for the treatment of breast cancer. Adenosine 5′-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming and reverse the “Warburg effect” via multiple metabolic signaling pathways in breast cancer. Previous studies suggest that the activation of AMPK suppresses the growth and metastasis of breast cancer cells, as well as stimulating the responses of immune cells. However, some other reports claim that the development and poor prognosis of breast cancer are related to the overexpression and aberrant activation of AMPK. Thus, the role of AMPK in the progression of breast cancer is still controversial. In this review, we summarize the current understanding of AMPK, particularly the comprehensive bidirectional functions of AMPK in cancer progression; discuss the pharmacological activators of AMPK and some specific molecules, including the natural products (including berberine, curcumin, (−)-epigallocatechin-3-gallate, ginsenosides, and paclitaxel) that influence the efficacy of these activators in cancer therapy; and elaborate the role of AMPK as a potential therapeutic target for the treatment of breast cancer. MDPI 2023-01-11 /pmc/articles/PMC9863744/ /pubmed/36677797 http://dx.doi.org/10.3390/molecules28020740 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Peng, Bo Zhang, Si-Yuan Chan, Ka Iong Zhong, Zhang-Feng Wang, Yi-Tao Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title | Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title_full | Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title_fullStr | Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title_full_unstemmed | Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title_short | Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer |
title_sort | novel anti-cancer products targeting ampk: natural herbal medicine against breast cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863744/ https://www.ncbi.nlm.nih.gov/pubmed/36677797 http://dx.doi.org/10.3390/molecules28020740 |
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