Specific Binding of the α-Component of the Lantibiotic Lichenicidin to the Peptidoglycan Precursor Lipid II Predetermines Its Antimicrobial Activity

To date, a number of lantibiotics have been shown to use lipid II—a highly conserved peptidoglycan precursor in the cytoplasmic membrane of bacteria—as their molecular target. The α-component (Lchα) of the two-component lantibiotic lichenicidin, previously isolated from the Bacillus licheniformis VK...

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Detalles Bibliográficos
Autores principales: Panina, Irina S., Balandin, Sergey V., Tsarev, Andrey V., Chugunov, Anton O., Tagaev, Andrey A., Finkina, Ekaterina I., Antoshina, Daria V., Sheremeteva, Elvira V., Paramonov, Alexander S., Rickmeyer, Jasmin, Bierbaum, Gabriele, Efremov, Roman G., Shenkarev, Zakhar O., Ovchinnikova, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863751/
https://www.ncbi.nlm.nih.gov/pubmed/36674846
http://dx.doi.org/10.3390/ijms24021332

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