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The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation poi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863798/ https://www.ncbi.nlm.nih.gov/pubmed/36668758 http://dx.doi.org/10.3390/toxics11010032 |
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author | Zhang, Xing Flaws, Jodi A. Spinella, Michael J. Irudayaraj, Joseph |
author_facet | Zhang, Xing Flaws, Jodi A. Spinella, Michael J. Irudayaraj, Joseph |
author_sort | Zhang, Xing |
collection | PubMed |
description | Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized. |
format | Online Article Text |
id | pubmed-9863798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98637982023-01-22 The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease Zhang, Xing Flaws, Jodi A. Spinella, Michael J. Irudayaraj, Joseph Toxics Review Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized. MDPI 2022-12-29 /pmc/articles/PMC9863798/ /pubmed/36668758 http://dx.doi.org/10.3390/toxics11010032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Xing Flaws, Jodi A. Spinella, Michael J. Irudayaraj, Joseph The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title | The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title_full | The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title_fullStr | The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title_full_unstemmed | The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title_short | The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease |
title_sort | relationship between typical environmental endocrine disruptors and kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863798/ https://www.ncbi.nlm.nih.gov/pubmed/36668758 http://dx.doi.org/10.3390/toxics11010032 |
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