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The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation poi...

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Autores principales: Zhang, Xing, Flaws, Jodi A., Spinella, Michael J., Irudayaraj, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863798/
https://www.ncbi.nlm.nih.gov/pubmed/36668758
http://dx.doi.org/10.3390/toxics11010032
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author Zhang, Xing
Flaws, Jodi A.
Spinella, Michael J.
Irudayaraj, Joseph
author_facet Zhang, Xing
Flaws, Jodi A.
Spinella, Michael J.
Irudayaraj, Joseph
author_sort Zhang, Xing
collection PubMed
description Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.
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spelling pubmed-98637982023-01-22 The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease Zhang, Xing Flaws, Jodi A. Spinella, Michael J. Irudayaraj, Joseph Toxics Review Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized. MDPI 2022-12-29 /pmc/articles/PMC9863798/ /pubmed/36668758 http://dx.doi.org/10.3390/toxics11010032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Xing
Flaws, Jodi A.
Spinella, Michael J.
Irudayaraj, Joseph
The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title_full The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title_fullStr The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title_full_unstemmed The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title_short The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease
title_sort relationship between typical environmental endocrine disruptors and kidney disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863798/
https://www.ncbi.nlm.nih.gov/pubmed/36668758
http://dx.doi.org/10.3390/toxics11010032
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