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Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders

Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have...

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Autores principales: Kolesarova, Mariana, Simko, Patrik, Urbanska, Nicol, Kiskova, Terezia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863859/
https://www.ncbi.nlm.nih.gov/pubmed/36678832
http://dx.doi.org/10.3390/pharmaceutics15010204
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author Kolesarova, Mariana
Simko, Patrik
Urbanska, Nicol
Kiskova, Terezia
author_facet Kolesarova, Mariana
Simko, Patrik
Urbanska, Nicol
Kiskova, Terezia
author_sort Kolesarova, Mariana
collection PubMed
description Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases.
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spelling pubmed-98638592023-01-22 Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders Kolesarova, Mariana Simko, Patrik Urbanska, Nicol Kiskova, Terezia Pharmaceutics Review Cannabinoids have a major therapeutic value in a variety of disorders. The concepts of cannabinoids are difficult to develop, but they can be used and are advantageous for a number of diseases that are not sufficiently managed by existing treatments. Nanoconjugation and encapsulation techniques have been shown to be effective in improving the delivery and the therapeutic effectiveness of drugs that are poorly soluble in water. Because the bioavailability of cannabinoids is low, the challenge is to explore different administration methods to improve their effectiveness. Because cannabinoids cross the blood-brain-barrier (BBB), they modify the negative effects of inflammatory processes on the BBB and may be a key factor in the improvement of BBB function after ischemic disease or other conditions. This review discusses various types of cannabinoid administration, as well as nanotechnologies used to improve the bioavailability of these compounds in CNS diseases. MDPI 2023-01-06 /pmc/articles/PMC9863859/ /pubmed/36678832 http://dx.doi.org/10.3390/pharmaceutics15010204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kolesarova, Mariana
Simko, Patrik
Urbanska, Nicol
Kiskova, Terezia
Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title_full Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title_fullStr Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title_full_unstemmed Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title_short Exploring the Potential of Cannabinoid Nanodelivery Systems for CNS Disorders
title_sort exploring the potential of cannabinoid nanodelivery systems for cns disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863859/
https://www.ncbi.nlm.nih.gov/pubmed/36678832
http://dx.doi.org/10.3390/pharmaceutics15010204
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