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Macrophages and Intervertebral Disc Degeneration
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individua...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863885/ https://www.ncbi.nlm.nih.gov/pubmed/36674887 http://dx.doi.org/10.3390/ijms24021367 |
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author | Koroth, Jinsha Buko, Erick O. Abbott, Rebecca Johnson, Casey P. Ogle, Brenda M. Stone, Laura S. Ellingson, Arin M. Bradley, Elizabeth W. |
author_facet | Koroth, Jinsha Buko, Erick O. Abbott, Rebecca Johnson, Casey P. Ogle, Brenda M. Stone, Laura S. Ellingson, Arin M. Bradley, Elizabeth W. |
author_sort | Koroth, Jinsha |
collection | PubMed |
description | The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration is a disease of the whole joint that is associated with significant inflammation. Moreover, studies show elevated macrophage accumulation within the IVD with increasing levels of disease severity; however, we still need to understand the roles, be they causative or consequential, of macrophages during the degenerative process. In this narrative review, we discuss hallmarks of IVD degeneration, showcase evidence of macrophage involvement during disc degeneration, and explore burgeoning research aimed at understanding the molecular pathways regulating macrophage functions during intervertebral disc degeneration. |
format | Online Article Text |
id | pubmed-9863885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98638852023-01-22 Macrophages and Intervertebral Disc Degeneration Koroth, Jinsha Buko, Erick O. Abbott, Rebecca Johnson, Casey P. Ogle, Brenda M. Stone, Laura S. Ellingson, Arin M. Bradley, Elizabeth W. Int J Mol Sci Review The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the spine. With little inherent regenerative capacity, degeneration of the intervertebral disc results in intervertebral disc disease, which contributes to low back pain and significant disability in many individuals. Increasing evidence suggests that IVD degeneration is a disease of the whole joint that is associated with significant inflammation. Moreover, studies show elevated macrophage accumulation within the IVD with increasing levels of disease severity; however, we still need to understand the roles, be they causative or consequential, of macrophages during the degenerative process. In this narrative review, we discuss hallmarks of IVD degeneration, showcase evidence of macrophage involvement during disc degeneration, and explore burgeoning research aimed at understanding the molecular pathways regulating macrophage functions during intervertebral disc degeneration. MDPI 2023-01-10 /pmc/articles/PMC9863885/ /pubmed/36674887 http://dx.doi.org/10.3390/ijms24021367 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Koroth, Jinsha Buko, Erick O. Abbott, Rebecca Johnson, Casey P. Ogle, Brenda M. Stone, Laura S. Ellingson, Arin M. Bradley, Elizabeth W. Macrophages and Intervertebral Disc Degeneration |
title | Macrophages and Intervertebral Disc Degeneration |
title_full | Macrophages and Intervertebral Disc Degeneration |
title_fullStr | Macrophages and Intervertebral Disc Degeneration |
title_full_unstemmed | Macrophages and Intervertebral Disc Degeneration |
title_short | Macrophages and Intervertebral Disc Degeneration |
title_sort | macrophages and intervertebral disc degeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863885/ https://www.ncbi.nlm.nih.gov/pubmed/36674887 http://dx.doi.org/10.3390/ijms24021367 |
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