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The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health?
Plant viruses have traditionally been studied as pathogens in the context of understanding the molecular and cellular mechanisms of a particular disease affecting crops. In recent years, viruses have emerged as a new alternative for producing biological nanomaterials and chimeric vaccines. Plant vir...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863966/ https://www.ncbi.nlm.nih.gov/pubmed/36675043 http://dx.doi.org/10.3390/ijms24021533 |
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author | Zahmanova, Gergana Aljabali, Alaa A. Takova, Katerina Toneva, Valentina Tambuwala, Murtaza M. Andonov, Anton P. Lukov, Georgi L. Minkov, Ivan |
author_facet | Zahmanova, Gergana Aljabali, Alaa A. Takova, Katerina Toneva, Valentina Tambuwala, Murtaza M. Andonov, Anton P. Lukov, Georgi L. Minkov, Ivan |
author_sort | Zahmanova, Gergana |
collection | PubMed |
description | Plant viruses have traditionally been studied as pathogens in the context of understanding the molecular and cellular mechanisms of a particular disease affecting crops. In recent years, viruses have emerged as a new alternative for producing biological nanomaterials and chimeric vaccines. Plant viruses were also used to generate highly efficient expression vectors, revolutionizing plant molecular farming (PMF). Several biological products, including recombinant vaccines, monoclonal antibodies, diagnostic reagents, and other pharmaceutical products produced in plants, have passed their clinical trials and are in their market implementation stage. PMF offers opportunities for fast, adaptive, and low-cost technology to meet ever-growing and critical global health needs. In this review, we summarized the advancements in the virus-like particles-based (VLPs-based) nanotechnologies and the role they played in the production of advanced vaccines, drugs, diagnostic bio-nanomaterials, and other bioactive cargos. We also highlighted various applications and advantages plant-produced vaccines have and their relevance for treating human and animal illnesses. Furthermore, we summarized the plant-based biologics that have passed through clinical trials, the unique challenges they faced, and the challenges they will face to qualify, become available, and succeed on the market. |
format | Online Article Text |
id | pubmed-9863966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98639662023-01-22 The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? Zahmanova, Gergana Aljabali, Alaa A. Takova, Katerina Toneva, Valentina Tambuwala, Murtaza M. Andonov, Anton P. Lukov, Georgi L. Minkov, Ivan Int J Mol Sci Review Plant viruses have traditionally been studied as pathogens in the context of understanding the molecular and cellular mechanisms of a particular disease affecting crops. In recent years, viruses have emerged as a new alternative for producing biological nanomaterials and chimeric vaccines. Plant viruses were also used to generate highly efficient expression vectors, revolutionizing plant molecular farming (PMF). Several biological products, including recombinant vaccines, monoclonal antibodies, diagnostic reagents, and other pharmaceutical products produced in plants, have passed their clinical trials and are in their market implementation stage. PMF offers opportunities for fast, adaptive, and low-cost technology to meet ever-growing and critical global health needs. In this review, we summarized the advancements in the virus-like particles-based (VLPs-based) nanotechnologies and the role they played in the production of advanced vaccines, drugs, diagnostic bio-nanomaterials, and other bioactive cargos. We also highlighted various applications and advantages plant-produced vaccines have and their relevance for treating human and animal illnesses. Furthermore, we summarized the plant-based biologics that have passed through clinical trials, the unique challenges they faced, and the challenges they will face to qualify, become available, and succeed on the market. MDPI 2023-01-12 /pmc/articles/PMC9863966/ /pubmed/36675043 http://dx.doi.org/10.3390/ijms24021533 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zahmanova, Gergana Aljabali, Alaa A. Takova, Katerina Toneva, Valentina Tambuwala, Murtaza M. Andonov, Anton P. Lukov, Georgi L. Minkov, Ivan The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title | The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title_full | The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title_fullStr | The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title_full_unstemmed | The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title_short | The Plant Viruses and Molecular Farming: How Beneficial They Might Be for Human and Animal Health? |
title_sort | plant viruses and molecular farming: how beneficial they might be for human and animal health? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863966/ https://www.ncbi.nlm.nih.gov/pubmed/36675043 http://dx.doi.org/10.3390/ijms24021533 |
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