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Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability

The present study aimed to investigate the physical stability in terms of (droplet size, pH, and ionic strength) and chemical stability in terms of (retention) of D-limonene (LM) in the nanoemulsions after emulsification as well as after storing them for 30 days under different temperatures (5 °C, 2...

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Autores principales: Sohan, Md Sohanur Rahman, Elshamy, Samar, Lara-Valderrama, Grace, Changwatchai, Teetach, Khadizatul, Kubra, Kobayashi, Isao, Nakajima, Mitsutoshi, Neves, Marcos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864102/
https://www.ncbi.nlm.nih.gov/pubmed/36679351
http://dx.doi.org/10.3390/polym15020471
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author Sohan, Md Sohanur Rahman
Elshamy, Samar
Lara-Valderrama, Grace
Changwatchai, Teetach
Khadizatul, Kubra
Kobayashi, Isao
Nakajima, Mitsutoshi
Neves, Marcos A.
author_facet Sohan, Md Sohanur Rahman
Elshamy, Samar
Lara-Valderrama, Grace
Changwatchai, Teetach
Khadizatul, Kubra
Kobayashi, Isao
Nakajima, Mitsutoshi
Neves, Marcos A.
author_sort Sohan, Md Sohanur Rahman
collection PubMed
description The present study aimed to investigate the physical stability in terms of (droplet size, pH, and ionic strength) and chemical stability in terms of (retention) of D-limonene (LM) in the nanoemulsions after emulsification as well as after storing them for 30 days under different temperatures (5 °C, 25 °C, and 50 °C). LM is a cyclic monoterpene and a major component extracted from citrus fruits. The modification of disperse phase with soybean oil (SB) and a nonionic emulsifier (Tween 80) was adequate to prepare stable LM-loaded nanoemulsions. LM blended with SB-loaded nanoemulsions were stable against droplet growth over pH (3–9) and ionic strength (0–500 mM NaCl). Regarding long-term storage, the prepared nanoemulsions demonstrated excellent physical stability with droplet size ranging from 120–130 nm during 30 days of storage at both 5 °C and 25 °C; however, oiling off started in the emulsions, which were stored at 50 °C from day 10. On the other hand, the retention of LM in the emulsions was significantly impacted by storage temperature. Nanoemulsions stored at 5 °C had the highest retention of 91%, while nanoemulsions stored at 25 °C had the lowest retention of 82%.
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spelling pubmed-98641022023-01-22 Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability Sohan, Md Sohanur Rahman Elshamy, Samar Lara-Valderrama, Grace Changwatchai, Teetach Khadizatul, Kubra Kobayashi, Isao Nakajima, Mitsutoshi Neves, Marcos A. Polymers (Basel) Article The present study aimed to investigate the physical stability in terms of (droplet size, pH, and ionic strength) and chemical stability in terms of (retention) of D-limonene (LM) in the nanoemulsions after emulsification as well as after storing them for 30 days under different temperatures (5 °C, 25 °C, and 50 °C). LM is a cyclic monoterpene and a major component extracted from citrus fruits. The modification of disperse phase with soybean oil (SB) and a nonionic emulsifier (Tween 80) was adequate to prepare stable LM-loaded nanoemulsions. LM blended with SB-loaded nanoemulsions were stable against droplet growth over pH (3–9) and ionic strength (0–500 mM NaCl). Regarding long-term storage, the prepared nanoemulsions demonstrated excellent physical stability with droplet size ranging from 120–130 nm during 30 days of storage at both 5 °C and 25 °C; however, oiling off started in the emulsions, which were stored at 50 °C from day 10. On the other hand, the retention of LM in the emulsions was significantly impacted by storage temperature. Nanoemulsions stored at 5 °C had the highest retention of 91%, while nanoemulsions stored at 25 °C had the lowest retention of 82%. MDPI 2023-01-16 /pmc/articles/PMC9864102/ /pubmed/36679351 http://dx.doi.org/10.3390/polym15020471 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sohan, Md Sohanur Rahman
Elshamy, Samar
Lara-Valderrama, Grace
Changwatchai, Teetach
Khadizatul, Kubra
Kobayashi, Isao
Nakajima, Mitsutoshi
Neves, Marcos A.
Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title_full Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title_fullStr Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title_full_unstemmed Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title_short Encapsulation of D-Limonene into O/W Nanoemulsions for Enhanced Stability
title_sort encapsulation of d-limonene into o/w nanoemulsions for enhanced stability
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864102/
https://www.ncbi.nlm.nih.gov/pubmed/36679351
http://dx.doi.org/10.3390/polym15020471
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