Cargando…

Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature

(1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on...

Descripción completa

Detalles Bibliográficos
Autores principales: Kopanou Taliaka, Paschalia, Tsantes, Andreas G., Konstantinidi, Aikaterini, Houhoula, Dimitra, Tsante, Konstantina A., Vaiopoulos, Aristeidis G., Piovani, Daniele, Nikolopoulos, Georgios K., Bonovas, Stefanos, Iacovidou, Nicoletta, Tsantes, Argirios E., Sokou, Rozeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864123/
https://www.ncbi.nlm.nih.gov/pubmed/36676116
http://dx.doi.org/10.3390/life13010167
_version_ 1784875505158193152
author Kopanou Taliaka, Paschalia
Tsantes, Andreas G.
Konstantinidi, Aikaterini
Houhoula, Dimitra
Tsante, Konstantina A.
Vaiopoulos, Aristeidis G.
Piovani, Daniele
Nikolopoulos, Georgios K.
Bonovas, Stefanos
Iacovidou, Nicoletta
Tsantes, Argirios E.
Sokou, Rozeta
author_facet Kopanou Taliaka, Paschalia
Tsantes, Andreas G.
Konstantinidi, Aikaterini
Houhoula, Dimitra
Tsante, Konstantina A.
Vaiopoulos, Aristeidis G.
Piovani, Daniele
Nikolopoulos, Georgios K.
Bonovas, Stefanos
Iacovidou, Nicoletta
Tsantes, Argirios E.
Sokou, Rozeta
author_sort Kopanou Taliaka, Paschalia
collection PubMed
description (1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on neonatal liver abscesses due to invasive fungal infections. (2) Methods: An electronic search of the PubMed and Scopus databases was conducted, considering studies that evaluated fungal liver abscesses in the neonatal population. Data on the epidemiology, clinical course, treatment, and outcome of these infections were integrated in our study. (3) Results: Overall, 10 studies were included presenting data on 19 cases of neonatal fungal liver abscesses. Candida spp. were the most common causative pathogens (94.7%). Premature neonates constituted the majority of cases (93%), while umbilical venous catheter placement, broad spectrum antibiotics, and prolonged parenteral nutrition administration were identified as other common predisposing factors. Diagnosis was established primarily by abdominal ultrasonography. Medical therapy with antifungal agents was the mainstay of treatment, with Amphotericin B being the most common agent (47%). Abscess drainage was required in four cases (21%). Eradication of the infection was achieved in the majority of cases (80%). (4) Conclusions: Even though fungal liver abscess is a rare entity in the neonatal population, clinicians should keep it in mind in small, premature infants who fail to respond to conventional treatment for sepsis, particularly if an indwelling catheter is in situ. A high index of suspicion is necessary in order to achieve a timely diagnosis and the initiation of the appropriate treatment.
format Online
Article
Text
id pubmed-9864123
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98641232023-01-22 Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature Kopanou Taliaka, Paschalia Tsantes, Andreas G. Konstantinidi, Aikaterini Houhoula, Dimitra Tsante, Konstantina A. Vaiopoulos, Aristeidis G. Piovani, Daniele Nikolopoulos, Georgios K. Bonovas, Stefanos Iacovidou, Nicoletta Tsantes, Argirios E. Sokou, Rozeta Life (Basel) Systematic Review (1) Background: Although invasive fungal infections are a major cause of neonatal morbidity and mortality, data on the incidence and outcomes of localized abscesses in solid organs due to fungal infections are scarce. The aim of this study was to consolidate evidence and enhance our understanding on neonatal liver abscesses due to invasive fungal infections. (2) Methods: An electronic search of the PubMed and Scopus databases was conducted, considering studies that evaluated fungal liver abscesses in the neonatal population. Data on the epidemiology, clinical course, treatment, and outcome of these infections were integrated in our study. (3) Results: Overall, 10 studies were included presenting data on 19 cases of neonatal fungal liver abscesses. Candida spp. were the most common causative pathogens (94.7%). Premature neonates constituted the majority of cases (93%), while umbilical venous catheter placement, broad spectrum antibiotics, and prolonged parenteral nutrition administration were identified as other common predisposing factors. Diagnosis was established primarily by abdominal ultrasonography. Medical therapy with antifungal agents was the mainstay of treatment, with Amphotericin B being the most common agent (47%). Abscess drainage was required in four cases (21%). Eradication of the infection was achieved in the majority of cases (80%). (4) Conclusions: Even though fungal liver abscess is a rare entity in the neonatal population, clinicians should keep it in mind in small, premature infants who fail to respond to conventional treatment for sepsis, particularly if an indwelling catheter is in situ. A high index of suspicion is necessary in order to achieve a timely diagnosis and the initiation of the appropriate treatment. MDPI 2023-01-06 /pmc/articles/PMC9864123/ /pubmed/36676116 http://dx.doi.org/10.3390/life13010167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kopanou Taliaka, Paschalia
Tsantes, Andreas G.
Konstantinidi, Aikaterini
Houhoula, Dimitra
Tsante, Konstantina A.
Vaiopoulos, Aristeidis G.
Piovani, Daniele
Nikolopoulos, Georgios K.
Bonovas, Stefanos
Iacovidou, Nicoletta
Tsantes, Argirios E.
Sokou, Rozeta
Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title_full Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title_fullStr Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title_full_unstemmed Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title_short Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature
title_sort risk factors, diagnosis, and treatment of neonatal fungal liver abscess: a systematic review of the literature
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864123/
https://www.ncbi.nlm.nih.gov/pubmed/36676116
http://dx.doi.org/10.3390/life13010167
work_keys_str_mv AT kopanoutaliakapaschalia riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT tsantesandreasg riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT konstantinidiaikaterini riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT houhouladimitra riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT tsantekonstantinaa riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT vaiopoulosaristeidisg riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT piovanidaniele riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT nikolopoulosgeorgiosk riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT bonovasstefanos riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT iacovidounicoletta riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT tsantesargiriose riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature
AT sokourozeta riskfactorsdiagnosisandtreatmentofneonatalfungalliverabscessasystematicreviewoftheliterature