Mechanistic Investigation of the Androgen Receptor DNA-Binding Domain and Modulation via Direct Interactions with DNA Abasic Sites: Understanding the Mechanisms Involved in Castration-Resistant Prostate Cancer

The androgen receptor (AR) is an important drug target in prostate cancer and a driver of castration-resistant prostate cancer (CRPC). A significant challenge in designing effective drugs lies in targeting constitutively active AR variants and, most importantly, nearly all AR variants lacking the li...

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Detalles Bibliográficos
Autores principales: Xu, Shangze, Kondal, Matthew D., Ahmad, Ayaz, Zhu, Ruidi, Fan, Lanyu, Zaborniak, Piotr, Madden, Katrina S., de Souza, João V., Bronowska, Agnieszka K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864221/
https://www.ncbi.nlm.nih.gov/pubmed/36674785
http://dx.doi.org/10.3390/ijms24021270

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