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A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery

Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poo...

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Detalles Bibliográficos
Autores principales: Liu, Fangzhe, Wang, Zihan, Guo, Hui, Li, Haichao, Chen, Yulan, Guan, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864262/
https://www.ncbi.nlm.nih.gov/pubmed/36677557
http://dx.doi.org/10.3390/molecules28020499
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author Liu, Fangzhe
Wang, Zihan
Guo, Hui
Li, Haichao
Chen, Yulan
Guan, Shuang
author_facet Liu, Fangzhe
Wang, Zihan
Guo, Hui
Li, Haichao
Chen, Yulan
Guan, Shuang
author_sort Liu, Fangzhe
collection PubMed
description Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poor water retention. To solve these problems, we developed a double-layer (DL) hydrogel based on β-cyclodextrin polymer (β-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC) via a layer-by-layer method. Inspired by natural coconut, this hydrogel consisted of a drug release layer (DRL) and a mechanical support layer (MSL). In our design, the introduction of β-CDP into the DRL slowed the drug release rate of the DL hydrogel. Furthermore, the mechanical strength of the hydrogel was improved by immersing the MSL in a calcium chloride/boric acid solution. Combining these two layers, the tensile strength and elongation at break of the DL hydrogel reached 1504 kPa and 400%, respectively. More interestingly, the release mechanism of DL hydrogel conformed to the diffusion–relaxation–erosion model, which was different from traditional hydrogel dressings. Therefore, the as-prepared DL structure represents a feasible solution for fabricating high-performance mechanical hydrogel dressings with sustained drug release properties, and the DL hydrogel has potential to be used for medical dressings applied in daily life.
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spelling pubmed-98642622023-01-22 A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery Liu, Fangzhe Wang, Zihan Guo, Hui Li, Haichao Chen, Yulan Guan, Shuang Molecules Article Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poor water retention. To solve these problems, we developed a double-layer (DL) hydrogel based on β-cyclodextrin polymer (β-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC) via a layer-by-layer method. Inspired by natural coconut, this hydrogel consisted of a drug release layer (DRL) and a mechanical support layer (MSL). In our design, the introduction of β-CDP into the DRL slowed the drug release rate of the DL hydrogel. Furthermore, the mechanical strength of the hydrogel was improved by immersing the MSL in a calcium chloride/boric acid solution. Combining these two layers, the tensile strength and elongation at break of the DL hydrogel reached 1504 kPa and 400%, respectively. More interestingly, the release mechanism of DL hydrogel conformed to the diffusion–relaxation–erosion model, which was different from traditional hydrogel dressings. Therefore, the as-prepared DL structure represents a feasible solution for fabricating high-performance mechanical hydrogel dressings with sustained drug release properties, and the DL hydrogel has potential to be used for medical dressings applied in daily life. MDPI 2023-01-04 /pmc/articles/PMC9864262/ /pubmed/36677557 http://dx.doi.org/10.3390/molecules28020499 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Fangzhe
Wang, Zihan
Guo, Hui
Li, Haichao
Chen, Yulan
Guan, Shuang
A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title_full A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title_fullStr A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title_full_unstemmed A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title_short A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
title_sort double-layer hydrogel dressing with high mechanical strength and water resistance used for drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864262/
https://www.ncbi.nlm.nih.gov/pubmed/36677557
http://dx.doi.org/10.3390/molecules28020499
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