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A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery
Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864262/ https://www.ncbi.nlm.nih.gov/pubmed/36677557 http://dx.doi.org/10.3390/molecules28020499 |
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author | Liu, Fangzhe Wang, Zihan Guo, Hui Li, Haichao Chen, Yulan Guan, Shuang |
author_facet | Liu, Fangzhe Wang, Zihan Guo, Hui Li, Haichao Chen, Yulan Guan, Shuang |
author_sort | Liu, Fangzhe |
collection | PubMed |
description | Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poor water retention. To solve these problems, we developed a double-layer (DL) hydrogel based on β-cyclodextrin polymer (β-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC) via a layer-by-layer method. Inspired by natural coconut, this hydrogel consisted of a drug release layer (DRL) and a mechanical support layer (MSL). In our design, the introduction of β-CDP into the DRL slowed the drug release rate of the DL hydrogel. Furthermore, the mechanical strength of the hydrogel was improved by immersing the MSL in a calcium chloride/boric acid solution. Combining these two layers, the tensile strength and elongation at break of the DL hydrogel reached 1504 kPa and 400%, respectively. More interestingly, the release mechanism of DL hydrogel conformed to the diffusion–relaxation–erosion model, which was different from traditional hydrogel dressings. Therefore, the as-prepared DL structure represents a feasible solution for fabricating high-performance mechanical hydrogel dressings with sustained drug release properties, and the DL hydrogel has potential to be used for medical dressings applied in daily life. |
format | Online Article Text |
id | pubmed-9864262 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98642622023-01-22 A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery Liu, Fangzhe Wang, Zihan Guo, Hui Li, Haichao Chen, Yulan Guan, Shuang Molecules Article Hydrogel dressings provide a moist wound healing environment, absorb the exudates of the wound, and have better biocompatibility than traditional dressings. However, it is still difficult to meet the needs of modern medicine due to the defects in drug burst release, weak mechanical strength, and poor water retention. To solve these problems, we developed a double-layer (DL) hydrogel based on β-cyclodextrin polymer (β-CDP), poly(vinyl alcohol) (PVA), and carboxymethyl cellulose sodium (CMC) via a layer-by-layer method. Inspired by natural coconut, this hydrogel consisted of a drug release layer (DRL) and a mechanical support layer (MSL). In our design, the introduction of β-CDP into the DRL slowed the drug release rate of the DL hydrogel. Furthermore, the mechanical strength of the hydrogel was improved by immersing the MSL in a calcium chloride/boric acid solution. Combining these two layers, the tensile strength and elongation at break of the DL hydrogel reached 1504 kPa and 400%, respectively. More interestingly, the release mechanism of DL hydrogel conformed to the diffusion–relaxation–erosion model, which was different from traditional hydrogel dressings. Therefore, the as-prepared DL structure represents a feasible solution for fabricating high-performance mechanical hydrogel dressings with sustained drug release properties, and the DL hydrogel has potential to be used for medical dressings applied in daily life. MDPI 2023-01-04 /pmc/articles/PMC9864262/ /pubmed/36677557 http://dx.doi.org/10.3390/molecules28020499 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Fangzhe Wang, Zihan Guo, Hui Li, Haichao Chen, Yulan Guan, Shuang A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title | A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title_full | A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title_fullStr | A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title_full_unstemmed | A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title_short | A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery |
title_sort | double-layer hydrogel dressing with high mechanical strength and water resistance used for drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864262/ https://www.ncbi.nlm.nih.gov/pubmed/36677557 http://dx.doi.org/10.3390/molecules28020499 |
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