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Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension

Background: In patients with essential hypertension, a non-dipping blood pressure pattern is a strong risk factor for cardiovascular diseases. However, background factors associating with such a blood pressure pattern remain unknown. Methods: Untreated essential hypertensive patients without chronic...

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Autores principales: Koike, Tsutomu, Imamura, Teruhiko, Tomoda, Fumihiro, Ohara, Maiko, Fujioka, Hayato, Kakeshita, Kota, Yamazaki, Hidenori, Kinugawa, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864263/
https://www.ncbi.nlm.nih.gov/pubmed/36675499
http://dx.doi.org/10.3390/jcm12020570
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author Koike, Tsutomu
Imamura, Teruhiko
Tomoda, Fumihiro
Ohara, Maiko
Fujioka, Hayato
Kakeshita, Kota
Yamazaki, Hidenori
Kinugawa, Koichiro
author_facet Koike, Tsutomu
Imamura, Teruhiko
Tomoda, Fumihiro
Ohara, Maiko
Fujioka, Hayato
Kakeshita, Kota
Yamazaki, Hidenori
Kinugawa, Koichiro
author_sort Koike, Tsutomu
collection PubMed
description Background: In patients with essential hypertension, a non-dipping blood pressure pattern is a strong risk factor for cardiovascular diseases. However, background factors associating with such a blood pressure pattern remain unknown. Methods: Untreated essential hypertensive patients without chronic kidney diseases who were admitted to our outpatient clinic were included. Blood sampling and 24 h ambulatory blood pressure monitoring were mandatorily performed. Non-dipper status was defined as a maximum decrease in nocturnal systolic blood pressure within 10%. Clinical factors associating with non-dipper status were investigated. Results: A total of 154 patients (56 ± 12 years old, 86 men) were included. Among baseline characteristics, a higher serum uric acid level was independently associated with non-dipper status (odds ratio 1.03, 95% confidence interval 1.00–1.05, p < 0.05). Among those with non-dipper status, a higher high-sensitivity C-reactive protein level tended to be associated with incremental nighttime systolic blood pressure levels (p = 0.065). Conclusions: Hyperuricemia and micro-inflammation might be associated with attenuated nocturnal blood pressure dipping and incremental nighttime systolic blood pressure levels.
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spelling pubmed-98642632023-01-22 Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension Koike, Tsutomu Imamura, Teruhiko Tomoda, Fumihiro Ohara, Maiko Fujioka, Hayato Kakeshita, Kota Yamazaki, Hidenori Kinugawa, Koichiro J Clin Med Article Background: In patients with essential hypertension, a non-dipping blood pressure pattern is a strong risk factor for cardiovascular diseases. However, background factors associating with such a blood pressure pattern remain unknown. Methods: Untreated essential hypertensive patients without chronic kidney diseases who were admitted to our outpatient clinic were included. Blood sampling and 24 h ambulatory blood pressure monitoring were mandatorily performed. Non-dipper status was defined as a maximum decrease in nocturnal systolic blood pressure within 10%. Clinical factors associating with non-dipper status were investigated. Results: A total of 154 patients (56 ± 12 years old, 86 men) were included. Among baseline characteristics, a higher serum uric acid level was independently associated with non-dipper status (odds ratio 1.03, 95% confidence interval 1.00–1.05, p < 0.05). Among those with non-dipper status, a higher high-sensitivity C-reactive protein level tended to be associated with incremental nighttime systolic blood pressure levels (p = 0.065). Conclusions: Hyperuricemia and micro-inflammation might be associated with attenuated nocturnal blood pressure dipping and incremental nighttime systolic blood pressure levels. MDPI 2023-01-10 /pmc/articles/PMC9864263/ /pubmed/36675499 http://dx.doi.org/10.3390/jcm12020570 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koike, Tsutomu
Imamura, Teruhiko
Tomoda, Fumihiro
Ohara, Maiko
Fujioka, Hayato
Kakeshita, Kota
Yamazaki, Hidenori
Kinugawa, Koichiro
Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title_full Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title_fullStr Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title_full_unstemmed Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title_short Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension
title_sort factors associating with non-dipping pattern of nocturnal blood pressure in patients with essential hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864263/
https://www.ncbi.nlm.nih.gov/pubmed/36675499
http://dx.doi.org/10.3390/jcm12020570
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