Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China

A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm in Shandong Province, China, and its genome was sequenced. This pig farm has been using the VR-2332 vaccine strain to immunize pigs for a long ti...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Yang, Zhang, Tianying, Gong, Dengmei, Qi, Juan, Jiang, Shenghai, Yang, Hao, Zhu, Xianchang, Gan, Yu, Zhang, Yi, Han, Yanyan, Li, Yan, Li, Jida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864264/
https://www.ncbi.nlm.nih.gov/pubmed/36680205
http://dx.doi.org/10.3390/v15010165
_version_ 1784875540281294848
author Xia, Yang
Zhang, Tianying
Gong, Dengmei
Qi, Juan
Jiang, Shenghai
Yang, Hao
Zhu, Xianchang
Gan, Yu
Zhang, Yi
Han, Yanyan
Li, Yan
Li, Jida
author_facet Xia, Yang
Zhang, Tianying
Gong, Dengmei
Qi, Juan
Jiang, Shenghai
Yang, Hao
Zhu, Xianchang
Gan, Yu
Zhang, Yi
Han, Yanyan
Li, Yan
Li, Jida
author_sort Xia, Yang
collection PubMed
description A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm in Shandong Province, China, and its genome was sequenced. This pig farm has been using the VR-2332 vaccine strain to immunize pigs for a long time. The phylogenic and single nucleotide polymorphisms (SNPs) analysis of the viruses isolated from dead pigs showed that SD2020 was a natural recombinant virus of the VR-2332 vaccine strain and the JXA1 similar strain, and that two splicing fragments highly homologous to JXA1 in the virus genome were probably derived from the JXA1 wild strain and JXA1-R vaccine strain, respectively. Therefore, the possible recombination events of SD2020 and its mutation site might be related to high pathogenicity.
format Online
Article
Text
id pubmed-9864264
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98642642023-01-22 Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China Xia, Yang Zhang, Tianying Gong, Dengmei Qi, Juan Jiang, Shenghai Yang, Hao Zhu, Xianchang Gan, Yu Zhang, Yi Han, Yanyan Li, Yan Li, Jida Viruses Article A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm in Shandong Province, China, and its genome was sequenced. This pig farm has been using the VR-2332 vaccine strain to immunize pigs for a long time. The phylogenic and single nucleotide polymorphisms (SNPs) analysis of the viruses isolated from dead pigs showed that SD2020 was a natural recombinant virus of the VR-2332 vaccine strain and the JXA1 similar strain, and that two splicing fragments highly homologous to JXA1 in the virus genome were probably derived from the JXA1 wild strain and JXA1-R vaccine strain, respectively. Therefore, the possible recombination events of SD2020 and its mutation site might be related to high pathogenicity. MDPI 2023-01-05 /pmc/articles/PMC9864264/ /pubmed/36680205 http://dx.doi.org/10.3390/v15010165 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xia, Yang
Zhang, Tianying
Gong, Dengmei
Qi, Juan
Jiang, Shenghai
Yang, Hao
Zhu, Xianchang
Gan, Yu
Zhang, Yi
Han, Yanyan
Li, Yan
Li, Jida
Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title_full Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title_fullStr Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title_full_unstemmed Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title_short Recombination and Mutation in a New HP-PRRSV Strain (SD2020) from China
title_sort recombination and mutation in a new hp-prrsv strain (sd2020) from china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864264/
https://www.ncbi.nlm.nih.gov/pubmed/36680205
http://dx.doi.org/10.3390/v15010165
work_keys_str_mv AT xiayang recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT zhangtianying recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT gongdengmei recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT qijuan recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT jiangshenghai recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT yanghao recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT zhuxianchang recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT ganyu recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT zhangyi recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT hanyanyan recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT liyan recombinationandmutationinanewhpprrsvstrainsd2020fromchina
AT lijida recombinationandmutationinanewhpprrsvstrainsd2020fromchina

Ejemplares similares