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Toll-like Receptors and Thrombopoiesis
Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864288/ https://www.ncbi.nlm.nih.gov/pubmed/36674552 http://dx.doi.org/10.3390/ijms24021010 |
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author | Tang, Xiaoqin Xu, Qian Yang, Shuo Huang, Xinwu Wang, Long Huang, Feihong Luo, Jiesi Zhou, Xiaogang Wu, Anguo Mei, Qibing Zhao, Chunling Wu, Jianming |
author_facet | Tang, Xiaoqin Xu, Qian Yang, Shuo Huang, Xinwu Wang, Long Huang, Feihong Luo, Jiesi Zhou, Xiaogang Wu, Anguo Mei, Qibing Zhao, Chunling Wu, Jianming |
author_sort | Tang, Xiaoqin |
collection | PubMed |
description | Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it presents a proportional relationship with the fatality of many diseases. Therefore, the prevention and treatment of thrombocytopenia is of great importance. The expression of Toll-like receptors (TLRs) is one of the most relevant characteristics of thrombopoiesis and the platelet inflammatory function. We know that the TLR family is found on the surface or inside almost all cells, where they perform many immune functions. Of those, TLR2 and TLR4 are the main stress-inducing members and play an integral role in inflammatory diseases and platelet production and function. Therefore, the aim of this review is to present and discuss the relationship between platelets, inflammation and the TLR family and extend recent research on the influence of the TLR2 and TLR4 pathways and the regulation of platelet production and function. Reviewing the interaction between TLRs and platelets in inflammation may be a research direction or program for the treatment of thrombocytopenia-related and inflammatory-related diseases. |
format | Online Article Text |
id | pubmed-9864288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98642882023-01-22 Toll-like Receptors and Thrombopoiesis Tang, Xiaoqin Xu, Qian Yang, Shuo Huang, Xinwu Wang, Long Huang, Feihong Luo, Jiesi Zhou, Xiaogang Wu, Anguo Mei, Qibing Zhao, Chunling Wu, Jianming Int J Mol Sci Review Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it presents a proportional relationship with the fatality of many diseases. Therefore, the prevention and treatment of thrombocytopenia is of great importance. The expression of Toll-like receptors (TLRs) is one of the most relevant characteristics of thrombopoiesis and the platelet inflammatory function. We know that the TLR family is found on the surface or inside almost all cells, where they perform many immune functions. Of those, TLR2 and TLR4 are the main stress-inducing members and play an integral role in inflammatory diseases and platelet production and function. Therefore, the aim of this review is to present and discuss the relationship between platelets, inflammation and the TLR family and extend recent research on the influence of the TLR2 and TLR4 pathways and the regulation of platelet production and function. Reviewing the interaction between TLRs and platelets in inflammation may be a research direction or program for the treatment of thrombocytopenia-related and inflammatory-related diseases. MDPI 2023-01-05 /pmc/articles/PMC9864288/ /pubmed/36674552 http://dx.doi.org/10.3390/ijms24021010 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tang, Xiaoqin Xu, Qian Yang, Shuo Huang, Xinwu Wang, Long Huang, Feihong Luo, Jiesi Zhou, Xiaogang Wu, Anguo Mei, Qibing Zhao, Chunling Wu, Jianming Toll-like Receptors and Thrombopoiesis |
title | Toll-like Receptors and Thrombopoiesis |
title_full | Toll-like Receptors and Thrombopoiesis |
title_fullStr | Toll-like Receptors and Thrombopoiesis |
title_full_unstemmed | Toll-like Receptors and Thrombopoiesis |
title_short | Toll-like Receptors and Thrombopoiesis |
title_sort | toll-like receptors and thrombopoiesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864288/ https://www.ncbi.nlm.nih.gov/pubmed/36674552 http://dx.doi.org/10.3390/ijms24021010 |
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