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Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges

Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation...

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Detalles Bibliográficos
Autores principales: Pozharov, Vitaly P., Minko, Tamara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864317/
https://www.ncbi.nlm.nih.gov/pubmed/36678823
http://dx.doi.org/10.3390/pharmaceutics15010194
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author Pozharov, Vitaly P.
Minko, Tamara
author_facet Pozharov, Vitaly P.
Minko, Tamara
author_sort Pozharov, Vitaly P.
collection PubMed
description Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids.
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spelling pubmed-98643172023-01-22 Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges Pozharov, Vitaly P. Minko, Tamara Pharmaceutics Review Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at the stage of pre-clinical development and testing and did not find their way to the clinic. In our opinion, the main reason for this situation lies in the enormous complexity of the development and industrial production of such formulations leading to their high cost. The development of nanotechnology-based drugs requires the participation of scientists from many and completely different specialties including Pharmaceutical Sciences, Medicine, Engineering, Drug Delivery, Chemistry, Molecular Biology, Physiology and so on. Nevertheless, emergence of coronavirus and new vaccines based on nanotechnology has shown the high efficiency of this approach. Effective development of vaccines based on the use of nucleic acids and nanomedicine requires an understanding of a wide range of principles including mechanisms of immune responses, nucleic acid functions, nanotechnology and vaccinations. In this regard, the purpose of the current review is to recall the basic principles of the work of the immune system, vaccination, nanotechnology and drug delivery in terms of the development and production of vaccines based on both nanotechnology and the use of nucleic acids. MDPI 2023-01-05 /pmc/articles/PMC9864317/ /pubmed/36678823 http://dx.doi.org/10.3390/pharmaceutics15010194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pozharov, Vitaly P.
Minko, Tamara
Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title_full Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title_fullStr Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title_full_unstemmed Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title_short Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges
title_sort nanotechnology-based rna vaccines: fundamentals, advantages and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864317/
https://www.ncbi.nlm.nih.gov/pubmed/36678823
http://dx.doi.org/10.3390/pharmaceutics15010194
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