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Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells
Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment. The creation of nanocarriers to improve drug delivery and internalization effectiveness may be the solution to this issue. In this p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864328/ https://www.ncbi.nlm.nih.gov/pubmed/36677608 http://dx.doi.org/10.3390/molecules28020551 |
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author | Ziganshina, Albina Y. Mansurova, Elina E. Voloshina, Alexandra D. Lyubina, Anna P. Amerhanova, Syumbelya K. Shulaeva, Marina M. Nizameev, Irek R. Kadirov, Marsil K. Bakhtiozina, Leysan R. Semenov, Vyacheslav E. Antipin, Igor S. |
author_facet | Ziganshina, Albina Y. Mansurova, Elina E. Voloshina, Alexandra D. Lyubina, Anna P. Amerhanova, Syumbelya K. Shulaeva, Marina M. Nizameev, Irek R. Kadirov, Marsil K. Bakhtiozina, Leysan R. Semenov, Vyacheslav E. Antipin, Igor S. |
author_sort | Ziganshina, Albina Y. |
collection | PubMed |
description | Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment. The creation of nanocarriers to improve drug delivery and internalization effectiveness may be the solution to this issue. In this paper, we report on a new nanocarrier that was developed to deliver the anticancer drug doxorubicin to glioblastoma cells. The nanocarrier was obtained by nanoemulsion polymerization of diallyl disulfide with 1-allylthymine. Diallyl disulfide is a redox-sensitive molecule involved in redox cell activities, and thymine is a uracil derivative and one of the well-known bioactive compounds that can enhance the pharmacological activity of doxorubicin. Doxorubicin was successfully introduced into the nanocarrier with a load capacity of about 4.6%. Biological studies showed that the doxorubicin nanocarrier composition is far more cytotoxic to glioblastoma cells (T98G) than it is to cancer cells (M-HeLa) and healthy cells (Chang liver). The nanocarrier improves the penetration of doxorubicin into T98G cells and accelerates the cells’ demise, as is evident from flow cytometry and fluorescence microscopy data. The obtained nanocarrier, in our opinion, is a promising candidate for further research in glioblastoma therapy. |
format | Online Article Text |
id | pubmed-9864328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98643282023-01-22 Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells Ziganshina, Albina Y. Mansurova, Elina E. Voloshina, Alexandra D. Lyubina, Anna P. Amerhanova, Syumbelya K. Shulaeva, Marina M. Nizameev, Irek R. Kadirov, Marsil K. Bakhtiozina, Leysan R. Semenov, Vyacheslav E. Antipin, Igor S. Molecules Article Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment. The creation of nanocarriers to improve drug delivery and internalization effectiveness may be the solution to this issue. In this paper, we report on a new nanocarrier that was developed to deliver the anticancer drug doxorubicin to glioblastoma cells. The nanocarrier was obtained by nanoemulsion polymerization of diallyl disulfide with 1-allylthymine. Diallyl disulfide is a redox-sensitive molecule involved in redox cell activities, and thymine is a uracil derivative and one of the well-known bioactive compounds that can enhance the pharmacological activity of doxorubicin. Doxorubicin was successfully introduced into the nanocarrier with a load capacity of about 4.6%. Biological studies showed that the doxorubicin nanocarrier composition is far more cytotoxic to glioblastoma cells (T98G) than it is to cancer cells (M-HeLa) and healthy cells (Chang liver). The nanocarrier improves the penetration of doxorubicin into T98G cells and accelerates the cells’ demise, as is evident from flow cytometry and fluorescence microscopy data. The obtained nanocarrier, in our opinion, is a promising candidate for further research in glioblastoma therapy. MDPI 2023-01-05 /pmc/articles/PMC9864328/ /pubmed/36677608 http://dx.doi.org/10.3390/molecules28020551 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ziganshina, Albina Y. Mansurova, Elina E. Voloshina, Alexandra D. Lyubina, Anna P. Amerhanova, Syumbelya K. Shulaeva, Marina M. Nizameev, Irek R. Kadirov, Marsil K. Bakhtiozina, Leysan R. Semenov, Vyacheslav E. Antipin, Igor S. Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title | Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title_full | Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title_fullStr | Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title_full_unstemmed | Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title_short | Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells |
title_sort | thymine-modified nanocarrier for doxorubicin delivery in glioblastoma cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864328/ https://www.ncbi.nlm.nih.gov/pubmed/36677608 http://dx.doi.org/10.3390/molecules28020551 |
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