Cargando…
Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications
The search for new biocompatible materials that can replace invasive materials in biomedical applications has increased due to the great demand derived from accidents and diseases such as cancer in various tissues. In this sense, four formulations based on polycaprolactone (PCL) and polylactic acid...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864333/ https://www.ncbi.nlm.nih.gov/pubmed/36678672 http://dx.doi.org/10.3390/pharmaceutics15010043 |
_version_ | 1784875557607964672 |
---|---|
author | Grande-Tovar, Carlos David Castro, Jorge Iván Valencia Llano, Carlos Humberto Tenorio, Diego López Saavedra, Marcela Zapata, Paula A. Chaur, Manuel N. |
author_facet | Grande-Tovar, Carlos David Castro, Jorge Iván Valencia Llano, Carlos Humberto Tenorio, Diego López Saavedra, Marcela Zapata, Paula A. Chaur, Manuel N. |
author_sort | Grande-Tovar, Carlos David |
collection | PubMed |
description | The search for new biocompatible materials that can replace invasive materials in biomedical applications has increased due to the great demand derived from accidents and diseases such as cancer in various tissues. In this sense, four formulations based on polycaprolactone (PCL) and polylactic acid (PLA) incorporated with zinc oxide nanoparticles (ZnO-NPs) and tea tree essential oil (TTEO) were prepared. The sol-gel method was used for zinc oxide nanoparticle synthesis with an average size of 11 ± 2 nm and spherical morphology. On the other hand, Fourier Transformed infrared spectroscopy (FTIR) showed characteristic functional groups for each composite component. The TTEO incorporation in the formulations was related to the increased intensity of the C-O-C band. The thermal properties of the materials show that the degradative properties of the ZnO-NPs decrease the thermal stability. The morphological study by scanning electron microscopy (SEM) showed that the presence of TTEO and ZnO-NPs act synergistically, obtaining smooth surfaces, whereas membranes with the presence of ZnO-NPs or TTEO only show porous morphologies. Histological implantation of the membranes showed biocompatibility and biodegradability after 60 days of implantation. This degradation occurs through the fragmentation of the larger particles with the presence of connective tissue constituted by type III collagen fibers, blood vessels, and inflammatory cells, where the process of resorption of the implanted material continues. |
format | Online Article Text |
id | pubmed-9864333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98643332023-01-22 Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications Grande-Tovar, Carlos David Castro, Jorge Iván Valencia Llano, Carlos Humberto Tenorio, Diego López Saavedra, Marcela Zapata, Paula A. Chaur, Manuel N. Pharmaceutics Article The search for new biocompatible materials that can replace invasive materials in biomedical applications has increased due to the great demand derived from accidents and diseases such as cancer in various tissues. In this sense, four formulations based on polycaprolactone (PCL) and polylactic acid (PLA) incorporated with zinc oxide nanoparticles (ZnO-NPs) and tea tree essential oil (TTEO) were prepared. The sol-gel method was used for zinc oxide nanoparticle synthesis with an average size of 11 ± 2 nm and spherical morphology. On the other hand, Fourier Transformed infrared spectroscopy (FTIR) showed characteristic functional groups for each composite component. The TTEO incorporation in the formulations was related to the increased intensity of the C-O-C band. The thermal properties of the materials show that the degradative properties of the ZnO-NPs decrease the thermal stability. The morphological study by scanning electron microscopy (SEM) showed that the presence of TTEO and ZnO-NPs act synergistically, obtaining smooth surfaces, whereas membranes with the presence of ZnO-NPs or TTEO only show porous morphologies. Histological implantation of the membranes showed biocompatibility and biodegradability after 60 days of implantation. This degradation occurs through the fragmentation of the larger particles with the presence of connective tissue constituted by type III collagen fibers, blood vessels, and inflammatory cells, where the process of resorption of the implanted material continues. MDPI 2022-12-22 /pmc/articles/PMC9864333/ /pubmed/36678672 http://dx.doi.org/10.3390/pharmaceutics15010043 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grande-Tovar, Carlos David Castro, Jorge Iván Valencia Llano, Carlos Humberto Tenorio, Diego López Saavedra, Marcela Zapata, Paula A. Chaur, Manuel N. Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title | Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title_full | Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title_fullStr | Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title_full_unstemmed | Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title_short | Polycaprolactone (PCL)-Polylactic Acid (PLA)-Glycerol (Gly) Composites Incorporated with Zinc Oxide Nanoparticles (ZnO-NPs) and Tea Tree Essential Oil (TTEO) for Tissue Engineering Applications |
title_sort | polycaprolactone (pcl)-polylactic acid (pla)-glycerol (gly) composites incorporated with zinc oxide nanoparticles (zno-nps) and tea tree essential oil (tteo) for tissue engineering applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864333/ https://www.ncbi.nlm.nih.gov/pubmed/36678672 http://dx.doi.org/10.3390/pharmaceutics15010043 |
work_keys_str_mv | AT grandetovarcarlosdavid polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT castrojorgeivan polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT valenciallanocarloshumberto polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT tenoriodiegolopez polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT saavedramarcela polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT zapatapaulaa polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications AT chaurmanueln polycaprolactonepclpolylacticacidplaglycerolglycompositesincorporatedwithzincoxidenanoparticlesznonpsandteatreeessentialoiltteofortissueengineeringapplications |