Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico

Isoquinoline alkaloids constitute one of the most common classes of alkaloids that have shown a pronounced role in curing various diseases. Finding ways to reduce the toxicity of these molecules and to increase their therapeutic margin is an urgent matter. Here, a one-step method for the synthesis o...

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Detalles Bibliográficos
Autores principales: Azamatov, Azizbek A., Zhurakulov, Sherzod N., Vinogradova, Valentina I., Tursunkhodzhaeva, Firuza, Khinkar, Roaa M., Malatani, Rania T., Aldurdunji, Mohammed M., Tiezzi, Antonio, Mamadalieva, Nilufar Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864514/
https://www.ncbi.nlm.nih.gov/pubmed/36677539
http://dx.doi.org/10.3390/molecules28020477

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