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Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications
Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications. Another drawback of BC is the loss if its wa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864671/ https://www.ncbi.nlm.nih.gov/pubmed/36675235 http://dx.doi.org/10.3390/ijms24021719 |
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author | Isopencu, Gabriela Deleanu, Iuliana Busuioc, Cristina Oprea, Ovidiu Surdu, Vasile-Adrian Bacalum, Mihaela Stoica, Roberta Stoica-Guzun, Anicuţa |
author_facet | Isopencu, Gabriela Deleanu, Iuliana Busuioc, Cristina Oprea, Ovidiu Surdu, Vasile-Adrian Bacalum, Mihaela Stoica, Roberta Stoica-Guzun, Anicuţa |
author_sort | Isopencu, Gabriela |
collection | PubMed |
description | Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications. Another drawback of BC is the loss if its water retention capacity after dehydration. In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites. Citric acid (CA) was used as the crosslinking agent. These composites were tested as potential antimicrobial wound dressing materials. TE-loaded BC–CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior. Swelling tests and curcumin-release kinetic analysis were also performed. All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds. The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans). The in vitro cytotoxicity toward L929 fibroblast cells was studied as well. The obtained results allow us to recommend these composites as good candidates for wound dressing applications. |
format | Online Article Text |
id | pubmed-9864671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98646712023-01-22 Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications Isopencu, Gabriela Deleanu, Iuliana Busuioc, Cristina Oprea, Ovidiu Surdu, Vasile-Adrian Bacalum, Mihaela Stoica, Roberta Stoica-Guzun, Anicuţa Int J Mol Sci Article Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications. Another drawback of BC is the loss if its water retention capacity after dehydration. In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites. Citric acid (CA) was used as the crosslinking agent. These composites were tested as potential antimicrobial wound dressing materials. TE-loaded BC–CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior. Swelling tests and curcumin-release kinetic analysis were also performed. All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds. The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans). The in vitro cytotoxicity toward L929 fibroblast cells was studied as well. The obtained results allow us to recommend these composites as good candidates for wound dressing applications. MDPI 2023-01-15 /pmc/articles/PMC9864671/ /pubmed/36675235 http://dx.doi.org/10.3390/ijms24021719 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Isopencu, Gabriela Deleanu, Iuliana Busuioc, Cristina Oprea, Ovidiu Surdu, Vasile-Adrian Bacalum, Mihaela Stoica, Roberta Stoica-Guzun, Anicuţa Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title | Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title_full | Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title_fullStr | Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title_full_unstemmed | Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title_short | Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications |
title_sort | bacterial cellulose—carboxymethylcellulose composite loaded with turmeric extract for antimicrobial wound dressing applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864671/ https://www.ncbi.nlm.nih.gov/pubmed/36675235 http://dx.doi.org/10.3390/ijms24021719 |
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