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The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review

Neurodegenerative diseases are highly prevalent but poorly understood, and with few treatment options despite decades of intense research, attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the...

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Detalles Bibliográficos
Autores principales: Matheson, Julie-Anne T., Holsinger, R. M. Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864694/
https://www.ncbi.nlm.nih.gov/pubmed/36674517
http://dx.doi.org/10.3390/ijms24021001
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author Matheson, Julie-Anne T.
Holsinger, R. M. Damian
author_facet Matheson, Julie-Anne T.
Holsinger, R. M. Damian
author_sort Matheson, Julie-Anne T.
collection PubMed
description Neurodegenerative diseases are highly prevalent but poorly understood, and with few treatment options despite decades of intense research, attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the gut microbiome, which communicates with the brain through the gut–brain axis and has been implicated in various neurological disorders. Alterations in the gut microbiome have been associated with numerous neurological and other diseases, and restoration of the dysbiotic gut has been shown to improve disease conditions. One method of restoring a dysbiotic gut is via fecal microbiota transplantation (FMT), recolonizing the “diseased” gut with normal microbiome. Fecal microbiota transplantation is a treatment method traditionally used for Clostridium difficile infections, but it has recently been used in neurodegenerative disease research as a potential treatment method. This review aims to present a summary of neurodegenerative research that has used FMT, whether as a treatment or to investigate how the microbiome influences pathogenesis.
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spelling pubmed-98646942023-01-22 The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review Matheson, Julie-Anne T. Holsinger, R. M. Damian Int J Mol Sci Review Neurodegenerative diseases are highly prevalent but poorly understood, and with few treatment options despite decades of intense research, attention has recently shifted toward other mediators of neurological disease that may present future targets for therapeutic research. One such mediator is the gut microbiome, which communicates with the brain through the gut–brain axis and has been implicated in various neurological disorders. Alterations in the gut microbiome have been associated with numerous neurological and other diseases, and restoration of the dysbiotic gut has been shown to improve disease conditions. One method of restoring a dysbiotic gut is via fecal microbiota transplantation (FMT), recolonizing the “diseased” gut with normal microbiome. Fecal microbiota transplantation is a treatment method traditionally used for Clostridium difficile infections, but it has recently been used in neurodegenerative disease research as a potential treatment method. This review aims to present a summary of neurodegenerative research that has used FMT, whether as a treatment or to investigate how the microbiome influences pathogenesis. MDPI 2023-01-05 /pmc/articles/PMC9864694/ /pubmed/36674517 http://dx.doi.org/10.3390/ijms24021001 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matheson, Julie-Anne T.
Holsinger, R. M. Damian
The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title_full The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title_fullStr The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title_full_unstemmed The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title_short The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review
title_sort role of fecal microbiota transplantation in the treatment of neurodegenerative diseases: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864694/
https://www.ncbi.nlm.nih.gov/pubmed/36674517
http://dx.doi.org/10.3390/ijms24021001
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