The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment

Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such...

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Detalles Bibliográficos
Autores principales: Das, Sanjna, Hayden, Joshua, Sullivan, Travis, Rieger-Christ, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864802/
https://www.ncbi.nlm.nih.gov/pubmed/36674480
http://dx.doi.org/10.3390/ijms24020964
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author Das, Sanjna
Hayden, Joshua
Sullivan, Travis
Rieger-Christ, Kimberly
author_facet Das, Sanjna
Hayden, Joshua
Sullivan, Travis
Rieger-Christ, Kimberly
author_sort Das, Sanjna
collection PubMed
description Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such as a limited supply of BCG and identifying cases likely to recur, it would be advantageous to use molecular biomarkers to determine likelihood of recurrence and treatment response. Here, we review microRNAs (miRNAs) that have shown promise as predictors of BCa recurrence. MiRNAs are also discussed in the context of predicting resistance or susceptibility to BCa treatment.
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spelling pubmed-98648022023-01-22 The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment Das, Sanjna Hayden, Joshua Sullivan, Travis Rieger-Christ, Kimberly Int J Mol Sci Review Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such as a limited supply of BCG and identifying cases likely to recur, it would be advantageous to use molecular biomarkers to determine likelihood of recurrence and treatment response. Here, we review microRNAs (miRNAs) that have shown promise as predictors of BCa recurrence. MiRNAs are also discussed in the context of predicting resistance or susceptibility to BCa treatment. MDPI 2023-01-04 /pmc/articles/PMC9864802/ /pubmed/36674480 http://dx.doi.org/10.3390/ijms24020964 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Das, Sanjna
Hayden, Joshua
Sullivan, Travis
Rieger-Christ, Kimberly
The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title_full The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title_fullStr The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title_full_unstemmed The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title_short The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment
title_sort roles of mirnas in predicting bladder cancer recurrence and resistance to treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864802/
https://www.ncbi.nlm.nih.gov/pubmed/36674480
http://dx.doi.org/10.3390/ijms24020964
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