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Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammator...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864809/ https://www.ncbi.nlm.nih.gov/pubmed/36678706 http://dx.doi.org/10.3390/pharmaceutics15010077 |
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author | Parfenyuk, Elena Dolinina, Ekaterina |
author_facet | Parfenyuk, Elena Dolinina, Ekaterina |
author_sort | Parfenyuk, Elena |
collection | PubMed |
description | Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties. |
format | Online Article Text |
id | pubmed-9864809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98648092023-01-22 Silica Hydrogels as Platform for Delivery of Hyaluronic Acid Parfenyuk, Elena Dolinina, Ekaterina Pharmaceutics Article Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties. MDPI 2022-12-26 /pmc/articles/PMC9864809/ /pubmed/36678706 http://dx.doi.org/10.3390/pharmaceutics15010077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Parfenyuk, Elena Dolinina, Ekaterina Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title | Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title_full | Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title_fullStr | Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title_full_unstemmed | Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title_short | Silica Hydrogels as Platform for Delivery of Hyaluronic Acid |
title_sort | silica hydrogels as platform for delivery of hyaluronic acid |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864809/ https://www.ncbi.nlm.nih.gov/pubmed/36678706 http://dx.doi.org/10.3390/pharmaceutics15010077 |
work_keys_str_mv | AT parfenyukelena silicahydrogelsasplatformfordeliveryofhyaluronicacid AT dolininaekaterina silicahydrogelsasplatformfordeliveryofhyaluronicacid |