Cargando…

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammator...

Descripción completa

Detalles Bibliográficos
Autores principales: Parfenyuk, Elena, Dolinina, Ekaterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864809/
https://www.ncbi.nlm.nih.gov/pubmed/36678706
http://dx.doi.org/10.3390/pharmaceutics15010077
_version_ 1784875676538503168
author Parfenyuk, Elena
Dolinina, Ekaterina
author_facet Parfenyuk, Elena
Dolinina, Ekaterina
author_sort Parfenyuk, Elena
collection PubMed
description Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties.
format Online
Article
Text
id pubmed-9864809
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-98648092023-01-22 Silica Hydrogels as Platform for Delivery of Hyaluronic Acid Parfenyuk, Elena Dolinina, Ekaterina Pharmaceutics Article Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties. MDPI 2022-12-26 /pmc/articles/PMC9864809/ /pubmed/36678706 http://dx.doi.org/10.3390/pharmaceutics15010077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Parfenyuk, Elena
Dolinina, Ekaterina
Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title_full Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title_fullStr Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title_full_unstemmed Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title_short Silica Hydrogels as Platform for Delivery of Hyaluronic Acid
title_sort silica hydrogels as platform for delivery of hyaluronic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864809/
https://www.ncbi.nlm.nih.gov/pubmed/36678706
http://dx.doi.org/10.3390/pharmaceutics15010077
work_keys_str_mv AT parfenyukelena silicahydrogelsasplatformfordeliveryofhyaluronicacid
AT dolininaekaterina silicahydrogelsasplatformfordeliveryofhyaluronicacid