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Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics

Long Covid can affect anyone who has previously had acute COVID-19. The root causes of this syndrome are still unknown, and no effective therapeutics are available. This complex syndrome, with a wide array of symptoms, is still evolving. Given the dire situation, it is important to identify the caus...

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Autores principales: Haque, Azizul, Pant, Anudeep B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864843/
https://www.ncbi.nlm.nih.gov/pubmed/36680082
http://dx.doi.org/10.3390/v15010042
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author Haque, Azizul
Pant, Anudeep B.
author_facet Haque, Azizul
Pant, Anudeep B.
author_sort Haque, Azizul
collection PubMed
description Long Covid can affect anyone who has previously had acute COVID-19. The root causes of this syndrome are still unknown, and no effective therapeutics are available. This complex syndrome, with a wide array of symptoms, is still evolving. Given the dire situation, it is important to identify the causes of Long Covid and the changes occurring within the immune system of affected patients to figure out how to treat it. The immune system intersects with the persistent viral fragments and blood clots that are implicated in this syndrome; understanding how these complex systems interact may help in untangling the puzzling physiopathology of Long Covid and identifying mitigation measures to provide patients some relief. In this paper, we discuss evidence-based findings and formulate hypotheses on the mechanisms underlying Long Covid’s physiopathology and propose potential therapeutic options.
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spelling pubmed-98648432023-01-22 Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics Haque, Azizul Pant, Anudeep B. Viruses Review Long Covid can affect anyone who has previously had acute COVID-19. The root causes of this syndrome are still unknown, and no effective therapeutics are available. This complex syndrome, with a wide array of symptoms, is still evolving. Given the dire situation, it is important to identify the causes of Long Covid and the changes occurring within the immune system of affected patients to figure out how to treat it. The immune system intersects with the persistent viral fragments and blood clots that are implicated in this syndrome; understanding how these complex systems interact may help in untangling the puzzling physiopathology of Long Covid and identifying mitigation measures to provide patients some relief. In this paper, we discuss evidence-based findings and formulate hypotheses on the mechanisms underlying Long Covid’s physiopathology and propose potential therapeutic options. MDPI 2022-12-22 /pmc/articles/PMC9864843/ /pubmed/36680082 http://dx.doi.org/10.3390/v15010042 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Haque, Azizul
Pant, Anudeep B.
Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title_full Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title_fullStr Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title_full_unstemmed Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title_short Long Covid: Untangling the Complex Syndrome and the Search for Therapeutics
title_sort long covid: untangling the complex syndrome and the search for therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864843/
https://www.ncbi.nlm.nih.gov/pubmed/36680082
http://dx.doi.org/10.3390/v15010042
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