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Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics
Synaptic activity is the main energy-consuming process in the central nervous system. We are beginning to understand how energy is supplied and used during synaptic activity by neurons. However, the long-term metabolic adaptations associated with a previous episode of synaptic activity are not well...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864932/ https://www.ncbi.nlm.nih.gov/pubmed/36674431 http://dx.doi.org/10.3390/ijms24020922 |
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author | Tena-Morraja, Paula Riqué-Pujol, Guillem Müller-Sánchez, Claudia Reina, Manuel Martínez-Estrada, Ofelia M. Soriano, Francesc X. |
author_facet | Tena-Morraja, Paula Riqué-Pujol, Guillem Müller-Sánchez, Claudia Reina, Manuel Martínez-Estrada, Ofelia M. Soriano, Francesc X. |
author_sort | Tena-Morraja, Paula |
collection | PubMed |
description | Synaptic activity is the main energy-consuming process in the central nervous system. We are beginning to understand how energy is supplied and used during synaptic activity by neurons. However, the long-term metabolic adaptations associated with a previous episode of synaptic activity are not well understood. Herein, we show that an episode of synaptic activity increases mitochondrial bioenergetics beyond the duration of the synaptic activity by transcriptionally inducing the expression of iron metabolism genes with the consequent enhancement of cellular and mitochondrial iron uptake. Iron is a necessary component of the electron transport chain complexes, and its chelation or knockdown of mitochondrial iron transporter Mfrn1 blocks the activity-mediated bioenergetics boost. We found that Mfrn1 expression is regulated by the well-known regulator of synaptic plasticity CREB, suggesting the coordinated expression of synaptic plasticity programs with those required to meet the associated increase in energetic demands. |
format | Online Article Text |
id | pubmed-9864932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98649322023-01-22 Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics Tena-Morraja, Paula Riqué-Pujol, Guillem Müller-Sánchez, Claudia Reina, Manuel Martínez-Estrada, Ofelia M. Soriano, Francesc X. Int J Mol Sci Article Synaptic activity is the main energy-consuming process in the central nervous system. We are beginning to understand how energy is supplied and used during synaptic activity by neurons. However, the long-term metabolic adaptations associated with a previous episode of synaptic activity are not well understood. Herein, we show that an episode of synaptic activity increases mitochondrial bioenergetics beyond the duration of the synaptic activity by transcriptionally inducing the expression of iron metabolism genes with the consequent enhancement of cellular and mitochondrial iron uptake. Iron is a necessary component of the electron transport chain complexes, and its chelation or knockdown of mitochondrial iron transporter Mfrn1 blocks the activity-mediated bioenergetics boost. We found that Mfrn1 expression is regulated by the well-known regulator of synaptic plasticity CREB, suggesting the coordinated expression of synaptic plasticity programs with those required to meet the associated increase in energetic demands. MDPI 2023-01-04 /pmc/articles/PMC9864932/ /pubmed/36674431 http://dx.doi.org/10.3390/ijms24020922 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tena-Morraja, Paula Riqué-Pujol, Guillem Müller-Sánchez, Claudia Reina, Manuel Martínez-Estrada, Ofelia M. Soriano, Francesc X. Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title | Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title_full | Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title_fullStr | Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title_full_unstemmed | Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title_short | Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics |
title_sort | synaptic activity regulates mitochondrial iron metabolism to enhance neuronal bioenergetics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864932/ https://www.ncbi.nlm.nih.gov/pubmed/36674431 http://dx.doi.org/10.3390/ijms24020922 |
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