Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain

Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical and structural approaches. Screening of 107,600 sm...

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Detalles Bibliográficos
Autores principales: Virtanen, Anniina T., Haikarainen, Teemu, Sampathkumar, Parthasarathy, Palmroth, Maaria, Liukkonen, Sanna, Liu, Jianping, Nekhotiaeva, Natalia, Hubbard, Stevan R., Silvennoinen, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865020/
https://www.ncbi.nlm.nih.gov/pubmed/36678572
http://dx.doi.org/10.3390/ph16010075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865020/
https://www.ncbi.nlm.nih.gov/pubmed/36678572
http://dx.doi.org/10.3390/ph16010075

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