Switching Heavy Chain Constant Domains Denatures the Paratope 3D Architecture of Influenza Monoclonal Antibodies

Several human monoclonal Abs for treating Influenza have been evaluated in clinical trials with limited success despite demonstrating superiority in preclinical animal models including mice. To conduct efficacy studies in mice, human monoclonal Abs are genetically engineered to contain mouse heavy c...

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Detalles Bibliográficos
Autores principales: Malisheni, Moffat M., Chong, Cheng-Shoong, Murali, Tanusya M., Purushotorman, Kiren, Qian, Xinlei, Laiman, Alfred, Tan, Yee-Joo, MacAry, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865026/
https://www.ncbi.nlm.nih.gov/pubmed/36678399
http://dx.doi.org/10.3390/pathogens12010051

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