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A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable?
The aim of the study was to retrospectively evaluate the consistency of longitudinal findings on intellectual functioning in DMD boys and their relationship to behavioral and neuropsychiatric difficulties. The cohort included 70 patients of age 3 to 17 years with at least two assessments using the W...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865074/ https://www.ncbi.nlm.nih.gov/pubmed/36675332 http://dx.doi.org/10.3390/jcm12020403 |
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author | Chieffo, Daniela P. R. Moriconi, Federica Pane, Marika Lucibello, Simona Ferraroli, Elisabetta Norcia, Giulia Ricci, Martina Capasso, Anna Cicala, Gianpaolo Buchignani, Bianca Coratti, Giorgia Cutrona, Costanza Pelizzari, Monia Brogna, Claudia Hendriksen, Jos G. M. Muntoni, Francesco Mercuri, Eugenio |
author_facet | Chieffo, Daniela P. R. Moriconi, Federica Pane, Marika Lucibello, Simona Ferraroli, Elisabetta Norcia, Giulia Ricci, Martina Capasso, Anna Cicala, Gianpaolo Buchignani, Bianca Coratti, Giorgia Cutrona, Costanza Pelizzari, Monia Brogna, Claudia Hendriksen, Jos G. M. Muntoni, Francesco Mercuri, Eugenio |
author_sort | Chieffo, Daniela P. R. |
collection | PubMed |
description | The aim of the study was to retrospectively evaluate the consistency of longitudinal findings on intellectual functioning in DMD boys and their relationship to behavioral and neuropsychiatric difficulties. The cohort included 70 patients of age 3 to 17 years with at least two assessments using the Wechsler scales. CBCL and clinical observation of behavior were also performed. Changes in total intelligence quotient were interpreted as stable or not stable using the reliable-change method. On the first assessment 43/70 had normal quotients, 18 borderline, 5 mild, and 4 moderate intellectual disability, while 27/70 had no behavioral disorders, 17 had abnormal CBCL, and 26 patients had clear signs of attention deficits despite normal CBCL. The remaining seven were untestable. The mean total intelligence quotient change in the cohort was −2.99 points (SD: 12.29). Stable results on TIQ were found in 63% of the paired assessments. A third of the consecutive cognitive assessments showed a difference of more than 11 points with changes up to 42 points. Boys with no behavioral/attention disorder had smaller changes than those with attention (p = 0.007) and behavioral disorders (p = 0.002). Changes in IQ may occur in Duchenne and are likely to be associated with behavioral or attention deficits. |
format | Online Article Text |
id | pubmed-9865074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98650742023-01-22 A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? Chieffo, Daniela P. R. Moriconi, Federica Pane, Marika Lucibello, Simona Ferraroli, Elisabetta Norcia, Giulia Ricci, Martina Capasso, Anna Cicala, Gianpaolo Buchignani, Bianca Coratti, Giorgia Cutrona, Costanza Pelizzari, Monia Brogna, Claudia Hendriksen, Jos G. M. Muntoni, Francesco Mercuri, Eugenio J Clin Med Article The aim of the study was to retrospectively evaluate the consistency of longitudinal findings on intellectual functioning in DMD boys and their relationship to behavioral and neuropsychiatric difficulties. The cohort included 70 patients of age 3 to 17 years with at least two assessments using the Wechsler scales. CBCL and clinical observation of behavior were also performed. Changes in total intelligence quotient were interpreted as stable or not stable using the reliable-change method. On the first assessment 43/70 had normal quotients, 18 borderline, 5 mild, and 4 moderate intellectual disability, while 27/70 had no behavioral disorders, 17 had abnormal CBCL, and 26 patients had clear signs of attention deficits despite normal CBCL. The remaining seven were untestable. The mean total intelligence quotient change in the cohort was −2.99 points (SD: 12.29). Stable results on TIQ were found in 63% of the paired assessments. A third of the consecutive cognitive assessments showed a difference of more than 11 points with changes up to 42 points. Boys with no behavioral/attention disorder had smaller changes than those with attention (p = 0.007) and behavioral disorders (p = 0.002). Changes in IQ may occur in Duchenne and are likely to be associated with behavioral or attention deficits. MDPI 2023-01-04 /pmc/articles/PMC9865074/ /pubmed/36675332 http://dx.doi.org/10.3390/jcm12020403 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chieffo, Daniela P. R. Moriconi, Federica Pane, Marika Lucibello, Simona Ferraroli, Elisabetta Norcia, Giulia Ricci, Martina Capasso, Anna Cicala, Gianpaolo Buchignani, Bianca Coratti, Giorgia Cutrona, Costanza Pelizzari, Monia Brogna, Claudia Hendriksen, Jos G. M. Muntoni, Francesco Mercuri, Eugenio A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title | A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title_full | A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title_fullStr | A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title_full_unstemmed | A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title_short | A Longitudinal Follow-Up Study of Intellectual Function in Duchenne Muscular Dystrophy over Age: Is It Really Stable? |
title_sort | longitudinal follow-up study of intellectual function in duchenne muscular dystrophy over age: is it really stable? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865074/ https://www.ncbi.nlm.nih.gov/pubmed/36675332 http://dx.doi.org/10.3390/jcm12020403 |
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