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Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum

Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glu...

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Autores principales: Li, Rui, Zhou, Qing-Ling, Chen, Shu-Tong, Tai, Min-Rui, Cai, Hong-Ying, Ding, Rui, Liu, Xiao-Fei, Chen, Jian-Ping, Luo, Lian-Xiang, Zhong, Sai-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865083/
https://www.ncbi.nlm.nih.gov/pubmed/36662191
http://dx.doi.org/10.3390/md21010018
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author Li, Rui
Zhou, Qing-Ling
Chen, Shu-Tong
Tai, Min-Rui
Cai, Hong-Ying
Ding, Rui
Liu, Xiao-Fei
Chen, Jian-Ping
Luo, Lian-Xiang
Zhong, Sai-Yi
author_facet Li, Rui
Zhou, Qing-Ling
Chen, Shu-Tong
Tai, Min-Rui
Cai, Hong-Ying
Ding, Rui
Liu, Xiao-Fei
Chen, Jian-Ping
Luo, Lian-Xiang
Zhong, Sai-Yi
author_sort Li, Rui
collection PubMed
description Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields.
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spelling pubmed-98650832023-01-22 Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum Li, Rui Zhou, Qing-Ling Chen, Shu-Tong Tai, Min-Rui Cai, Hong-Ying Ding, Rui Liu, Xiao-Fei Chen, Jian-Ping Luo, Lian-Xiang Zhong, Sai-Yi Mar Drugs Article Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields. MDPI 2022-12-26 /pmc/articles/PMC9865083/ /pubmed/36662191 http://dx.doi.org/10.3390/md21010018 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Rui
Zhou, Qing-Ling
Chen, Shu-Tong
Tai, Min-Rui
Cai, Hong-Ying
Ding, Rui
Liu, Xiao-Fei
Chen, Jian-Ping
Luo, Lian-Xiang
Zhong, Sai-Yi
Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title_full Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title_fullStr Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title_full_unstemmed Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title_short Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
title_sort chemical characterization and immunomodulatory activity of fucoidan from sargassum hemiphyllum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865083/
https://www.ncbi.nlm.nih.gov/pubmed/36662191
http://dx.doi.org/10.3390/md21010018
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