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Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glu...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865083/ https://www.ncbi.nlm.nih.gov/pubmed/36662191 http://dx.doi.org/10.3390/md21010018 |
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author | Li, Rui Zhou, Qing-Ling Chen, Shu-Tong Tai, Min-Rui Cai, Hong-Ying Ding, Rui Liu, Xiao-Fei Chen, Jian-Ping Luo, Lian-Xiang Zhong, Sai-Yi |
author_facet | Li, Rui Zhou, Qing-Ling Chen, Shu-Tong Tai, Min-Rui Cai, Hong-Ying Ding, Rui Liu, Xiao-Fei Chen, Jian-Ping Luo, Lian-Xiang Zhong, Sai-Yi |
author_sort | Li, Rui |
collection | PubMed |
description | Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields. |
format | Online Article Text |
id | pubmed-9865083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98650832023-01-22 Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum Li, Rui Zhou, Qing-Ling Chen, Shu-Tong Tai, Min-Rui Cai, Hong-Ying Ding, Rui Liu, Xiao-Fei Chen, Jian-Ping Luo, Lian-Xiang Zhong, Sai-Yi Mar Drugs Article Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields. MDPI 2022-12-26 /pmc/articles/PMC9865083/ /pubmed/36662191 http://dx.doi.org/10.3390/md21010018 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Rui Zhou, Qing-Ling Chen, Shu-Tong Tai, Min-Rui Cai, Hong-Ying Ding, Rui Liu, Xiao-Fei Chen, Jian-Ping Luo, Lian-Xiang Zhong, Sai-Yi Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title | Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title_full | Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title_fullStr | Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title_full_unstemmed | Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title_short | Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum |
title_sort | chemical characterization and immunomodulatory activity of fucoidan from sargassum hemiphyllum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865083/ https://www.ncbi.nlm.nih.gov/pubmed/36662191 http://dx.doi.org/10.3390/md21010018 |
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