A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity

Alzheimer’s disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide screen in Saccharomyces cerevisiae, using a library of 51...

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Detalles Bibliográficos
Autores principales: Picón-Pagès, Pol, Bosch-Morató, Mònica, Subirana, Laia, Rubio-Moscardó, Francisca, Guivernau, Biuse, Fanlo-Ucar, Hugo, Zeylan, Melisa Ece, Senyuz, Simge, Herrera-Fernández, Víctor, Vicente, Rubén, Fernández-Fernández, José M., García-Ojalvo, Jordi, Gursoy, Attila, Keskin, Ozlem, Oliva, Baldomero, Posas, Francesc, de Nadal, Eulàlia, Muñoz, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865122/
https://www.ncbi.nlm.nih.gov/pubmed/36674792
http://dx.doi.org/10.3390/ijms24021278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865122/
https://www.ncbi.nlm.nih.gov/pubmed/36674792
http://dx.doi.org/10.3390/ijms24021278

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