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No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with seve...

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Detalles Bibliográficos
Autores principales: Edridge, Arthur W. D., van den Brekel, Nathalie, Mukungu, Philly, Nakayima, Rachael, Bbosa, Samuel, Isagara, Peter, Boele van Hensbroek, Michael, van der Hoek, Lia, Kayiwa, John, Lutwama, Julius J., Idro, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865167/
https://www.ncbi.nlm.nih.gov/pubmed/36668928
http://dx.doi.org/10.3390/tropicalmed8010021
Descripción
Sumario:We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.