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No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with seve...

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Autores principales: Edridge, Arthur W. D., van den Brekel, Nathalie, Mukungu, Philly, Nakayima, Rachael, Bbosa, Samuel, Isagara, Peter, Boele van Hensbroek, Michael, van der Hoek, Lia, Kayiwa, John, Lutwama, Julius J., Idro, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865167/
https://www.ncbi.nlm.nih.gov/pubmed/36668928
http://dx.doi.org/10.3390/tropicalmed8010021
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author Edridge, Arthur W. D.
van den Brekel, Nathalie
Mukungu, Philly
Nakayima, Rachael
Bbosa, Samuel
Isagara, Peter
Boele van Hensbroek, Michael
van der Hoek, Lia
Kayiwa, John
Lutwama, Julius J.
Idro, Richard
author_facet Edridge, Arthur W. D.
van den Brekel, Nathalie
Mukungu, Philly
Nakayima, Rachael
Bbosa, Samuel
Isagara, Peter
Boele van Hensbroek, Michael
van der Hoek, Lia
Kayiwa, John
Lutwama, Julius J.
Idro, Richard
author_sort Edridge, Arthur W. D.
collection PubMed
description We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.
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spelling pubmed-98651672023-01-22 No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda Edridge, Arthur W. D. van den Brekel, Nathalie Mukungu, Philly Nakayima, Rachael Bbosa, Samuel Isagara, Peter Boele van Hensbroek, Michael van der Hoek, Lia Kayiwa, John Lutwama, Julius J. Idro, Richard Trop Med Infect Dis Communication We investigated whether Ntwetwe virus—a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy—was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case–control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period. MDPI 2022-12-27 /pmc/articles/PMC9865167/ /pubmed/36668928 http://dx.doi.org/10.3390/tropicalmed8010021 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Edridge, Arthur W. D.
van den Brekel, Nathalie
Mukungu, Philly
Nakayima, Rachael
Bbosa, Samuel
Isagara, Peter
Boele van Hensbroek, Michael
van der Hoek, Lia
Kayiwa, John
Lutwama, Julius J.
Idro, Richard
No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title_full No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title_fullStr No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title_full_unstemmed No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title_short No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda
title_sort no evidence of ntwetwe virus infections in children presenting to kiboga hospital, uganda
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865167/
https://www.ncbi.nlm.nih.gov/pubmed/36668928
http://dx.doi.org/10.3390/tropicalmed8010021
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