Combinational Inhibition of P-Glycoprotein-Mediated Etoposide Transport by Zosuquidar and Polysorbate 20

P-glycoprotein (P-gp) limits the oral absorption of drug substances. Potent small molecule P-gp inhibitors (e.g., zosuquidar) and nonionic surfactants (e.g., polysorbate 20) inhibit P-gp by proposedly different mechanisms. Therefore, it was hypothesised that a combination of zosuquidar and polysorba...

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Detalles Bibliográficos
Autores principales: Nielsen, Rasmus Blaaholm, Holm, René, Pijpers, Ils, Snoeys, Jan, Nielsen, Ulla Gro, Nielsen, Carsten Uhd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865188/
https://www.ncbi.nlm.nih.gov/pubmed/36678911
http://dx.doi.org/10.3390/pharmaceutics15010283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865188/
https://www.ncbi.nlm.nih.gov/pubmed/36678911
http://dx.doi.org/10.3390/pharmaceutics15010283

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