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Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila
Long noncoding RNAs (lncRNAs) have a crucial role in epigenetic, transcriptional and posttranscriptional regulation of gene expression. Many of these regulatory lncRNAs, such as MALAT1, NEAT1, HOTAIR, etc., are associated with different neurodegenerative diseases in humans. The lncRNAs produced by t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865238/ https://www.ncbi.nlm.nih.gov/pubmed/36675966 http://dx.doi.org/10.3390/life13010017 |
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author | Singh, Anand Kumar |
author_facet | Singh, Anand Kumar |
author_sort | Singh, Anand Kumar |
collection | PubMed |
description | Long noncoding RNAs (lncRNAs) have a crucial role in epigenetic, transcriptional and posttranscriptional regulation of gene expression. Many of these regulatory lncRNAs, such as MALAT1, NEAT1, HOTAIR, etc., are associated with different neurodegenerative diseases in humans. The lncRNAs produced by the hsrω gene are known to modulate neurotoxicity in polyQ and amyotrophic lateral sclerosis disease models of Drosophila. Elevated expression of hsrω lncRNAs exaggerates, while their genetic depletion through hsrω-RNAi or in an hsrω-null mutant background suppresses, the disease pathogenicity. This review discusses the possible mechanistic details and implications of the functions of hsrω lncRNAs in the modulation of neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-9865238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-98652382023-01-22 Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila Singh, Anand Kumar Life (Basel) Review Long noncoding RNAs (lncRNAs) have a crucial role in epigenetic, transcriptional and posttranscriptional regulation of gene expression. Many of these regulatory lncRNAs, such as MALAT1, NEAT1, HOTAIR, etc., are associated with different neurodegenerative diseases in humans. The lncRNAs produced by the hsrω gene are known to modulate neurotoxicity in polyQ and amyotrophic lateral sclerosis disease models of Drosophila. Elevated expression of hsrω lncRNAs exaggerates, while their genetic depletion through hsrω-RNAi or in an hsrω-null mutant background suppresses, the disease pathogenicity. This review discusses the possible mechanistic details and implications of the functions of hsrω lncRNAs in the modulation of neurodegenerative diseases. MDPI 2022-12-21 /pmc/articles/PMC9865238/ /pubmed/36675966 http://dx.doi.org/10.3390/life13010017 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Singh, Anand Kumar Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title | Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title_full | Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title_fullStr | Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title_full_unstemmed | Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title_short | Hsrω and Other lncRNAs in Neuronal Functions and Disorders in Drosophila |
title_sort | hsrω and other lncrnas in neuronal functions and disorders in drosophila |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865238/ https://www.ncbi.nlm.nih.gov/pubmed/36675966 http://dx.doi.org/10.3390/life13010017 |
work_keys_str_mv | AT singhanandkumar hsrōandotherlncrnasinneuronalfunctionsanddisordersindrosophila |