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Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center

Background and Objectives: The aim of this article is to present a single-surgeon, open retroperitoneal lymph node dissection (RPLND) series for testicular cancer in a high-volume center. Materials and Methods: We reviewed data from patients who underwent RPLND performed by an experienced surgeon at...

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Autores principales: Mottaran, Angelo, Ercolino, Amelio, Bianchi, Lorenzo, Piazza, Pietro, Manes, Francesco, Amirhassankhani, Sasan, Salvador, Marco, Chessa, Francesco, Corcioni, Beniamino, Bertaccini, Alessandro, Schiavina, Riccardo, Brunocilla, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865264/
https://www.ncbi.nlm.nih.gov/pubmed/36676757
http://dx.doi.org/10.3390/medicina59010133
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author Mottaran, Angelo
Ercolino, Amelio
Bianchi, Lorenzo
Piazza, Pietro
Manes, Francesco
Amirhassankhani, Sasan
Salvador, Marco
Chessa, Francesco
Corcioni, Beniamino
Bertaccini, Alessandro
Schiavina, Riccardo
Brunocilla, Eugenio
author_facet Mottaran, Angelo
Ercolino, Amelio
Bianchi, Lorenzo
Piazza, Pietro
Manes, Francesco
Amirhassankhani, Sasan
Salvador, Marco
Chessa, Francesco
Corcioni, Beniamino
Bertaccini, Alessandro
Schiavina, Riccardo
Brunocilla, Eugenio
author_sort Mottaran, Angelo
collection PubMed
description Background and Objectives: The aim of this article is to present a single-surgeon, open retroperitoneal lymph node dissection (RPLND) series for testicular cancer in a high-volume center. Materials and Methods: We reviewed data from patients who underwent RPLND performed by an experienced surgeon at our institution between 2000 and 2019. We evaluated surgical and perioperative outcomes, complications, Recurrence-Free Survival (RFS), Overall Survival (OS), and Cancer-Specific Survival (CSS). Results: RPLND was performed in primary and secondary settings in 21 (32%) and 44 (68%) patients, respectively. Median operative time was 180 min. Median hospital stay was 6 days. Complications occurred in 23 (35%) patients, with 9 (14%) events reported as Clavien grade ≥ 3. Patients in the primary RPLND group were significantly younger, more likely to have NSGCT, had higher clinical N0 and M0, and had higher nerve-sparing RPLND (all p ≤ 0.04) compared to those in the secondary RPLND group. In the median follow-up of 120 (56–180) months, 10 (15%) patients experienced recurrence. Finally, 20-year OS, CSS, and RFS were 89%, 92%, and 85%, respectively, with no significant difference in survival rates between primary vs. secondary RPLND subgroups (p = 0.64, p = 0.7, and p = 0.31, respectively). Conclusions: Open RPLND performed by an experienced high-volume surgeon achieves excellent oncological and functional outcomes supporting the centralization of these complex procedures.
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spelling pubmed-98652642023-01-22 Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center Mottaran, Angelo Ercolino, Amelio Bianchi, Lorenzo Piazza, Pietro Manes, Francesco Amirhassankhani, Sasan Salvador, Marco Chessa, Francesco Corcioni, Beniamino Bertaccini, Alessandro Schiavina, Riccardo Brunocilla, Eugenio Medicina (Kaunas) Article Background and Objectives: The aim of this article is to present a single-surgeon, open retroperitoneal lymph node dissection (RPLND) series for testicular cancer in a high-volume center. Materials and Methods: We reviewed data from patients who underwent RPLND performed by an experienced surgeon at our institution between 2000 and 2019. We evaluated surgical and perioperative outcomes, complications, Recurrence-Free Survival (RFS), Overall Survival (OS), and Cancer-Specific Survival (CSS). Results: RPLND was performed in primary and secondary settings in 21 (32%) and 44 (68%) patients, respectively. Median operative time was 180 min. Median hospital stay was 6 days. Complications occurred in 23 (35%) patients, with 9 (14%) events reported as Clavien grade ≥ 3. Patients in the primary RPLND group were significantly younger, more likely to have NSGCT, had higher clinical N0 and M0, and had higher nerve-sparing RPLND (all p ≤ 0.04) compared to those in the secondary RPLND group. In the median follow-up of 120 (56–180) months, 10 (15%) patients experienced recurrence. Finally, 20-year OS, CSS, and RFS were 89%, 92%, and 85%, respectively, with no significant difference in survival rates between primary vs. secondary RPLND subgroups (p = 0.64, p = 0.7, and p = 0.31, respectively). Conclusions: Open RPLND performed by an experienced high-volume surgeon achieves excellent oncological and functional outcomes supporting the centralization of these complex procedures. MDPI 2023-01-10 /pmc/articles/PMC9865264/ /pubmed/36676757 http://dx.doi.org/10.3390/medicina59010133 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mottaran, Angelo
Ercolino, Amelio
Bianchi, Lorenzo
Piazza, Pietro
Manes, Francesco
Amirhassankhani, Sasan
Salvador, Marco
Chessa, Francesco
Corcioni, Beniamino
Bertaccini, Alessandro
Schiavina, Riccardo
Brunocilla, Eugenio
Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title_full Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title_fullStr Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title_full_unstemmed Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title_short Twenty Years’ Experience in Retroperitoneal Lymph Node Dissection for Testicular Cancer in a Tertiary Referral Center
title_sort twenty years’ experience in retroperitoneal lymph node dissection for testicular cancer in a tertiary referral center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865264/
https://www.ncbi.nlm.nih.gov/pubmed/36676757
http://dx.doi.org/10.3390/medicina59010133
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